Prostaglandin E2 receptor type 2-selective agonist prevents the degeneration of articular cartilage in rabbit knees with traumatic instability.
Prostaglandin E2 receptor type 2-selective agonist prevents the degeneration of articular cartilage in rabbit knees with traumatic instability.
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DOI：
10.1186/ar3460
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发表时间：
2011
影响因子：
4.9
通讯作者：
Toguchida J
中科院分区：
文献类型：
--
作者：
Mitsui H;Aoyama T;Furu M;Ito K;Jin Y;Maruyama T;Kanaji T;Fujimura S;Sugihara H;Nishiura A;Otsuka T;Nakamura T;Toguchida J
骨关节炎（OA）是老年人残疾的常见原因。我们以前曾报道过前列腺素E2受体亚型EP 2的激动剂（一种EP 2激动剂）促进软骨和骨软骨缺损的再生。本研究的目的是分析这种激动剂在创伤性退变模型中对关节软骨的影响。通过切断兔前交叉韧带和部分切除内侧半月板建立创伤性退变模型。将兔分为5组; G-S（假手术）、G-C（无进一步处理）、G-0、G-80和G-400（分别单次关节内施用含有0、80和400 μg特异性EP 2激动剂ONO-8815 Ly的明胶水凝胶）。术后2周或12周观察关节软骨退变情况。ONO-8815 Ly在2周时防止软骨退变，这与抑制基质金属蛋白酶-13（MMP-13）表达有关。ONO-8815 Ly的作用未能持续，并且在术后12周未观察到任何作用。通过EP 2刺激前列腺素E2（PGE 2）可防止关节软骨在早期阶段发生退化。有了长期递送的系统，EP 2激动剂可能成为OA的新治疗工具。
Osteoarthritis (OA) is a common cause of disability in older adults. We have previously reported that an agonist for subtypes EP2 of the prostaglandin E2 receptor (an EP2 agonist) promotes the regeneration of chondral and osteochondral defects. The purpose of the current study is to analyze the effect of this agonist on articular cartilage in a model of traumatic degeneration. The model of traumatic degeneration was established through transection of the anterior cruciate ligament and partial resection of the medial meniscus of the rabbits. Rabbits were divided into 5 groups; G-S (sham operation), G-C (no further treatment), G-0, G-80, and G-400 (single intra-articular administration of gelatin hydrogel containing 0, 80, and 400 μg of the specific EP2 agonist, ONO-8815Ly, respectively). Degeneration of the articular cartilage was evaluated at 2 or 12 weeks after the operation. ONO-8815Ly prevented cartilage degeneration at 2 weeks, which was associated with the inhibition of matrix metalloproteinase-13 (MMP-13) expression. The effect of ONO-8815Ly failed to last, and no effects were observed at 12 weeks after the operation. Stimulation of prostaglandin E2 (PGE2) via EP2 prevents degeneration of the articular cartilage during the early stages. With a system to deliver it long term, the EP2 agonist could be a new therapeutic tool for OA.
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影响因子：
4
作者：
Nishitani, Kohei;Ito, Hiromu;Nakamura, Takashi
通讯作者：
Nakamura, Takashi
影响因子：
--
作者：
Li, Xin;Ellman, Michael;Muddasani, Prasuna;Wang, James H. -C.;Cs-Szabo, Gabriella;van Wijnen, Andre J.;Im, Hee-Jeong
通讯作者：
Im, Hee-Jeong
影响因子：
--
作者：
LIPPIELLO, L;YAMAMOTO, K;MANKIN, HJ
通讯作者：
MANKIN, HJ
影响因子：
4.8
作者：
Lowe, GN;Fu, YH;Hahn, TJ
通讯作者：
Hahn, TJ
DOI：
10.1097/01.blo.0000144854.66565.8f
发表时间：
2004-10-01
影响因子：
4.2
作者：
Goldring, SR;Goldring, MB
通讯作者：
Goldring, MB