Hydrogen Sulfide Restored the Diurnal Variation in Cardiac Function of Aging Mice.
Hydrogen Sulfide Restored the Diurnal Variation in Cardiac Function of Aging Mice.
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硫化氢恢复了衰老小鼠心脏功能的昼夜变化
DOI：
10.1155/2021/8841575
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发表时间：
2021
影响因子：
--
通讯作者：
Wu Y
中科院分区：
文献类型：
--
作者：
Zhang H;Dai J;Tian D;Xiao L;Xue H;Guo Q;Zhang X;Teng X;Jin S;Wu Y
本研究旨在探讨硫化氢对衰老小鼠心功能昼夜变化的影响及其可能机制。我们发现，射血分数（EF）和缩短分数（FS）在3个月大的小鼠表现出24小时内的昼夜变化。然而，在18个月大的小鼠中，昼夜变化被破坏，EF和FS下降。此外，18月龄小鼠血浆丙二醛（MDA）水平升高，H2S浓度和超氧化物歧化酶（SOD）活性降低。然后，使用CSE KO小鼠来确定内源性H2S与EF和FS的昼夜变化之间是否存在关系。CSE KO小鼠12 h平均EF和FS在黑暗和光照期间无差异，但血浆MDA水平升高，SOD活性降低，表明内源性H2S缺乏减弱了心功能的昼夜变化。为了确定氧化应激是否破坏了心脏功能的昼夜变化，采用D-半乳糖诱导的亚急性衰老小鼠。D-gal处理3个月后，暗期和光照期的12 h平均EF和FS均降低，而暗期和光照期的12 h平均EF和FS无差异。D-半乳糖组经NaHS处理3个月后，血浆MDA水平降低，SOD活性升高。D-gal+NaHS组的EF和FS在12 h光照期低于12 h黑暗期，符合正弦曲线。在18个月大的小鼠中也观察到了相同的发现。总之，我们的研究表明，心脏功能的昼夜变化与衰老小鼠中氧化应激增加和H2S水平降低有关。H2S可通过减轻氧化应激而恢复衰老小鼠心功能的昼夜变化。
The present study was performed to investigate whether H2S could restore the diurnal variation in cardiac function of aging mice and explore the potential mechanisms. We found that ejection fraction (EF) and fractional shortening (FS) in 3-month-old mice exhibited diurnal variations over a 24-hour period. However, the diurnal variations were disrupted in 18-month-old mice, and there was a decline in EF and FS. In addition, the plasma malondialdehyde (MDA) levels were increased, and H2S concentrations and superoxide dismutase (SOD) activities were decreased in 18-month-old mice. Then, CSE KO mice were used to determine if there was a relationship between endogenous H2S and diurnal variations in EF and FS. There was no difference in 12-hour averaged EF and FS between dark and light periods in CSE KO mice accompanying increased MDA levels and decreased SOD activities in plasma, indicating that deficiency of endogenous H2S blunted diurnal variations of cardiac function. To determine whether oxidative stress disrupted the diurnal variations in cardiac function, D-galactose-induced subacute aging mice were employed. After 3-month D-gal treatment, both 12-hour averaged EF and FS in dark or light periods were decreased; meanwhile, there was no difference in 12-hour averaged EF and FS between dark and light periods. After 3-month NaHS treatment in the D-gal group, the plasma MDA levels were decreased and SOD activities were increased. The EF and FS were lower during the 12-hour light period than those during the 12-hour dark period which was fit to sine curves in the D-gal+NaHS group. Identical findings were also observed in 18-month-old mice. In conclusion, our studies revealed that the disrupted diurnal variation in cardiac function was associated with increased oxidative stress and decreased H2S levels in aging mice. H2S could restore the diurnal variation in cardiac function of aging mice by reducing oxidative stress.
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影响因子：
5.6
作者：
Jin S;Tan B;Teng X;Meng R;Jiao X;Tian D;Xiao L;Xue H;Guo Q;Duan X;Wu Y
通讯作者：
Wu Y
影响因子：
10.5
作者：
Pekovic-Vaughan V;Gibbs J;Yoshitane H;Yang N;Pathiranage D;Guo B;Sagami A;Taguchi K;Bechtold D;Loudon A;Yamamoto M;Chan J;van der Horst GT;Fukada Y;Meng QJ
通讯作者：
Meng QJ
影响因子：
29
作者：
Rey G;Valekunja UK;Feeney KA;Wulund L;Milev NB;Stangherlin A;Ansel-Bollepalli L;Velagapudi V;O'Neill JS;Reddy AB
通讯作者：
Reddy AB
影响因子：
10.8
作者：
Alibhai, Faisal J.;Reitz, Cristine J.;Martino, Tami A.
通讯作者：
Martino, Tami A.
DOI：
10.18632/aging.101026
发表时间：
2016-09-27
期刊：
Aging
影响因子：
--
作者：
Perridon BW;Leuvenink HG;Hillebrands JL;van Goor H;Bos EM
通讯作者：
Bos EM