How expectations of pain elicited by consciously and unconsciously perceived cues unfold over time.
How expectations of pain elicited by consciously and unconsciously perceived cues unfold over time.
复制标题
DOI：
10.1016/j.neuroimage.2021.117985
复制
发表时间：
2021-07-15
期刊：
影响因子：
5.7
通讯作者：
Kong J
中科院分区：
文献类型：
--
作者：
Tu Y;Pantazis D;Wilson G;Khan S;Ahlfors S;Kong J
期望可以在短时间内塑造对疼痛的感知，但人们对感知的期望如何随着时间的推移而展开并调节疼痛知觉知之甚少。在这里，我们结合脑磁图（MEG）和机器学习方法来跟踪健康参与者（男女）疼痛预期的神经动力学。我们发现，以面部线索为条件的疼痛预期可以在线索出现后 150 毫秒至 1100 毫秒内从 MEG 中解码出来，但与有意识感知的线索相比，解码由无意识感知的线索引起的预期需要更多的时间，并且衰减得更快。此外，时间泛化的结果表明，解码基于线索的期望的神经动力学主要在线索呈现期间持续，但在线索呈现后短暂存在。最后，虽然有意识感知的线索引起的解码期望是基于线索呈现期间一系列时间受限的大脑区域，但在有意识和无意识感知的线索的线索呈现后，解码依赖于内侧前额叶皮层和前扣带皮层。这些发现揭示了疼痛预期期间有意识和无意识的期望处理，并可能通过证明期望线索的影响来增强临床护理。
Expectation can shape the perception of pain within a fraction of time, but little is known about how perceived expectation unfolds over time and modulates pain perception. Here, we combine magnetoencephalography (MEG) and machine learning approaches to track the neural dynamics of expectations of pain in healthy participants with both sexes. We found that the expectation of pain, as conditioned by facial cues, can be decoded from MEG as early as 150 ms and up to 1100 ms after cue onset, but decoding expectation elicited by unconsciously perceived cues requires more time and decays faster compared to consciously perceived ones. Also, results from temporal generalization suggest that neural dynamics of decoding cue-based expectation were predominately sustained during cue presentation but transient after cue presentation. Finally, although decoding expectation elicited by consciously perceived cues were based on a series of time-restricted brain regions during cue presentation decoding relied on the medial prefrontal cortex and anterior cingulate cortex after cue presentation for both consciously and unconsciously perceived cues. These findings reveal the conscious and unconscious processing of expectation during pain anticipation and may shed light on enhancing clinical care by demonstrating the impact of expectation cues.
登录
查看更多内容
影响因子：
16.6
作者：
Dobs, Katharina;Isik, Leyla;Kanwisher, Nancy
通讯作者：
Kanwisher, Nancy
影响因子：
7.4
作者：
GRACELY, RH;MCGRATH, P;DUBNER, R
通讯作者：
DUBNER, R
影响因子：
3.4
作者：
Besson, G.;Barragan-Jason, G.;Barbeau, E. J.
通讯作者：
Barbeau, E. J.
影响因子：
2.6
作者：
Goeleven, Ellen;De Raedt, Rudi;Verschuere, Bruno
通讯作者：
Verschuere, Bruno
影响因子：
5.7
作者：
Freeman S;Yu R;Egorova N;Chen X;Kirsch I;Claggett B;Kaptchuk TJ;Gollub RL;Kong J
通讯作者：
Kong J