Molecular recognition using corona phase complexes made of synthetic polymers adsorbed on carbon nanotubes.
Molecular recognition using corona phase complexes made of synthetic polymers adsorbed on carbon nanotubes.
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DOI：
10.1038/nnano.2013.236
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发表时间：
2013-12
影响因子：
38.3
通讯作者：
中科院分区：
文献类型：
--
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分子识别是治疗、化学催化和传感器设计的核心。这样做的基序通常涉及生物结构，如抗体和适体。这种生物识别的关键是由折叠和受约束的杂聚物组成，该杂聚物通过分子内力形成独特的三维结构，该三维结构产生能够识别特定分子的结合口袋或界面。在这项工作中，我们证明了合成的杂聚物可以通过吸附在纳米颗粒周围，特别是单壁碳纳米管（SWNT），形成电晕相，并导致特定分子的分子识别的新形式。这种现象被证明是通用的，与新的杂聚物识别复合物证明了三个不同的例子：核黄素，l-甲状腺素，雌二醇，每个预测使用2D表面相互作用的热力学模型。离解常数是连续可调的通过扰动的杂聚物的化学结构。此外，这些复合物可以用作新型的时空传感器的基础上调制的单壁碳纳米管的光电发射在近红外，我们通过跟踪核黄素在小鼠巨噬细胞中的扩散。
Molecular recognition is central to the design of therapeutics, chemical catalysis and sensors. Motifs for doing so most commonly involve biological structures such as antibodies and aptamers. The key to such biological recognition consists of a folded and constrained heteropolymer that, via intra-molecular forces, forms a unique three dimensional structure that creates a binding pocket or an interface able to recognize a specific molecule. In this work, we demonstrate that synthetic heteropolymers can be alternatively constrained by adsorption around a nanoparticle, and specifically a single walled carbon nanotube (SWNT), forming a corona phase and resulting in a new form of molecular recognition of specific molecules. The phenomenon is shown to be generic, with new heteropolymer recognition complexes demonstrated for three distinct examples: Riboflavin, l-thyroxine, and estradiol, each predicted using a 2D thermodynamic model of surface interactions. The dissociation constants are continuously tunable by perturbing the chemical structure of the heteropolymer. Moreover, these complexes can be used as new types of spatial-temporal sensors based on modulation of SWNT photoemission in the near-infrared, as we show by tracking riboflavin diffusion in murine macrophages.
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影响因子：
64.8
作者：
de Koning-Ward, Tania F.;Gilson, Paul R.;Boddey, Justin A.;Rug, Melanie;Smith, Brian J.;Papenfuss, Anthony T.;Sanders, Paul R.;Lundie, Rachel J.;Maier, Alexander G.;Cowman, Alan F.;Crabb, Brendan S.
通讯作者：
Crabb, Brendan S.
影响因子：
21.8
作者：
Kim, Jong-Ho;Heller, Daniel A.;Strano, Michael S.
通讯作者：
Strano, Michael S.
影响因子：
4
作者：
Choi, Jong Hyun;Strano, Michael S.
通讯作者：
Strano, Michael S.
影响因子：
56.9
作者：
O'Connell, MJ;Bachilo, SM;Smalley, RE
通讯作者：
Smalley, RE
影响因子：
3.3
作者：
Lin, Shangchao;Blankschtein, Daniel
通讯作者：
Blankschtein, Daniel