Very early predictors of adolescent depression and suicide attempts in children with attention-deficit/hyperactivity disorder.
Very early predictors of adolescent depression and suicide attempts in children with attention-deficit/hyperactivity disorder.
复制标题
DOI：
10.1001/archgenpsychiatry.2010.127
复制
发表时间：
2010-10
影响因子：
--
通讯作者：
Lahey, Benjamin B.
中科院分区：
文献类型：
--
作者：
Chronis-Tuscano, Andrea;Molina, Brooke S. G.;Pelham, William E.;Applegate, Brooks;Dahlke, Allison;Overmyer, Meghan;Lahey, Benjamin B.
青春期的重度抑郁症和心境恶劣与严重残疾、对心理健康服务的需求以及复发风险有关。青春期期间的具体自杀意念和尝试与显着的痛苦、发病率和完全自杀的风险尤其相关。检验患有注意力缺陷/多动障碍 (ADHD) 的幼儿在青春期患抑郁症和自杀意念和企图的风险增加的假设，并确定哪些患有 ADHD 的幼儿面临最大风险的早期预测因素。前瞻性随访研究。伊利诺伊州芝加哥和宾夕法尼亚州匹兹堡。对 125 名 4 至 6 岁符合 DSM-IV ADHD 标准的儿童和 123 名人口统计学匹配的无 ADHD 儿童进行前瞻性随访，在 6 至 14 岁（9 至 18 岁）评估期间进行 7 项抑郁症和自杀行为结构化诊断评估。 DSM-IV 抑郁症和自杀行为标准。与对照儿童相比，4 至 6 岁患有 ADHD 的儿童在 18 岁时满足 DSM-IV 重度抑郁症或心境恶劣标准（风险比为 4.32）以及尝试自杀（风险比为 3.60）的风险大大增加。然而，患有多动症的儿童中这些结果的风险存在显着差异。在 ADHD 组中，患有 ADHD 每种亚型的儿童均面临风险，但不良后果不同。女孩患抑郁症和自杀未遂的风险更大。母亲抑郁症以及 4 至 6 岁时儿童并发的情绪和行为问题预示着抑郁症和自杀行为。幼儿 ADHD 的所有亚型都可以有力地预测 5 至 13 年后的青少年抑郁症和/或自杀企图。此外，女性、母亲抑郁症和 4 至 6 岁时的并发症状可以预测哪些患有 ADHD 的儿童出现这些不良后果的风险最大。识别患有多动症的高危幼儿为早期预防试验奠定了基础，以降低日后抑郁和自杀行为的风险。
Major depression and dysthymia in adolescence are associated with substantial disability, need for mental health services, and risk for recurrence. Concrete suicidal ideation and attempts during adolescence are particularly associated with significant distress, morbidity, and risk for completed suicide. To test the hypothesis that young children with attention-deficit/hyperactivity disorder (ADHD) are at increased risk for depression and suicidal ideation and attempts during adolescence and to identify early predictors of which young children with ADHD are at greatest risk. Prospective follow-up study. Chicago, Illinois, and Pittsburgh, Pennsylvania. A cohort of 125 children who met DSM-IV criteria for ADHD at 4 to 6 years of age and 123 demographically matched comparison children without ADHD were prospectively followed up in 7 structured diagnostic assessments of depression and suicidal behavior in assessment years 6 through 14, spanning 9 through 18 years of age. DSM-IV criteria for depressive disorders and suicidal behavior. Children with ADHD at 4 to 6 years of age were at greatly increased risk for meeting DSM-IV criteria for major depression or dysthymia (hazard ratio, 4.32) and for attempting suicide (hazard ratio,3.60) through the age of 18 years relative to comparison children. There were marked variations in risk for these outcomes among children with ADHD, however. Within the ADHD group, children with each subtype of ADHD were at risk but for different adverse outcomes. Girls were at greater risk for depression and suicide attempts. Maternal depression and concurrent child emotional and behavior problems at 4 to 6 years of age predicted depression and suicidal behavior. All subtypes of ADHD in young children robustly predict adolescent depression and/or suicide attempts 5 to 13 years later. Furthermore, female sex, maternal depression, and concurrent symptoms at 4 to 6 years of age predict which children with ADHD are at greatest risk for these adverse outcomes. Identifying high-risk young children with ADHD sets the stage for early prevention trials to reduce risk for later depression and suicidal behavior.
登录
查看更多内容
影响因子：
3.6
作者：
Mannuzza, S;Klein, RG;Moulton, JL
通讯作者：
Moulton, JL
影响因子：
--
作者：
Lahey, BB;Pelham, WE;Willcutt, E
通讯作者：
Willcutt, E
影响因子：
6.9
作者：
McGirr, A.;Renaud, J.;Turecki, G.
通讯作者：
Turecki, G.
影响因子：
6.9
作者：
Biederman, J;Monuteaux, MC;Faraone, SV
通讯作者：
Faraone, SV
DOI：
10.1177/10634266060140030501
发表时间：
2006-09-01
影响因子：
1.9
作者：
Bagwell, Catherine L.;Molina, Brooke S. G.;Hoza, Betsy
通讯作者：
Hoza, Betsy