TFClass: expanding the classification of human transcription factors to their mammalian orthologs.
TFClass: expanding the classification of human transcription factors to their mammalian orthologs.
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DOI：
10.1093/nar/gkx987
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发表时间：
2018-01-04
影响因子：
14.9
通讯作者：
Dönitz J
中科院分区：
文献类型：
--
作者：
Wingender E;Schoeps T;Haubrock M;Krull M;Dönitz J
TFClass是根据真核转录因子（TF）的DNA结合结构域（DBD）对其进行分类的资源，可在http://tfclass.bioinf.med.uni-goettingen.de在线获得。TFClass的分类方案最初是为人类TF推导的，在这里扩展到哺乳动物的整个分类类别。结合不同来源的信息，人工核对检索到的哺乳动物TF序列，并应用广泛的系统发育分析，将来自41种哺乳动物的>39 000个TF归入TF类的超纲、纲、科和亚科。因此，TFClass现在以FASTA格式提供相应的序列集合，不同分类水平的序列标识和系统发育树，人类，小鼠，狗和牛基因组的预测TF结合位点以及与几个外部数据库的链接。特别是，所有那些也记录在TRANSFAC®数据库（因子表）中的TF都已链接，可以自由访问。TRANSFAC® FACTOR也可以通过自己的搜索界面查询。
TFClass is a resource that classifies eukaryotic transcription factors (TFs) according to their DNA-binding domains (DBDs), available online at http://tfclass.bioinf.med.uni-goettingen.de. The classification scheme of TFClass was originally derived for human TFs and is expanded here to the whole taxonomic class of mammalia. Combining information from different resources, checking manually the retrieved mammalian TFs sequences and applying extensive phylogenetic analyses, >39 000 TFs from up to 41 mammalian species were assigned to the Superclasses, Classes, Families and Subfamilies of TFClass. As a result, TFClass now provides the corresponding sequence collection in FASTA format, sequence logos and phylogenetic trees at different classification levels, predicted TF binding sites for human, mouse, dog and cow genomes as well as links to several external databases. In particular, all those TFs that are also documented in the TRANSFAC® database (FACTOR table) have been linked and can be freely accessed. TRANSFAC® FACTOR can also be queried through an own search interface.
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影响因子：
3
作者：
Löytynoja A;Goldman N
通讯作者：
Goldman N
影响因子：
14.9
作者：
Dereeper A;Guignon V;Blanc G;Audic S;Buffet S;Chevenet F;Dufayard JF;Guindon S;Lefort V;Lescot M;Claverie JM;Gascuel O
通讯作者：
Gascuel O
影响因子：
14.9
作者：
The UniProt Consortium
通讯作者：
The UniProt Consortium
影响因子：
3.7
作者：
Doenitz, Juergen;Wingender, Edgar
通讯作者：
Wingender, Edgar
影响因子：
14.9
作者：
Wingender E;Schoeps T;Dönitz J
通讯作者：
Dönitz J