Promoting axonal rewiring to improve outcome after stroke.
Promoting axonal rewiring to improve outcome after stroke.
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DOI：
10.1016/j.nbd.2009.11.009
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发表时间：
2010-02
影响因子：
6.1
通讯作者：
Carmichael ST
中科院分区：
文献类型：
--
作者：
Benowitz LI;Carmichael ST
中风后的几周和几个月通常会出现有限的功能恢复，许多研究表明，这种恢复与大脑功能组织的变化有关。因此，以安全有效的方式加强这种重组的措施可能有助于改善中风患者的预后。在此，我们回顾了在正常生理条件下的功能和解剖重组的一些证据，沿着的策略，增强这些过程和改善脑损伤后的动物模型的结果。这些策略包括抵消与髓鞘相关的轴突生长抑制剂，激活神经元的内在生长状态，增强生理活性和行为治疗。这些方法代表了一个显着偏离最近的重点神经保护，并可能提供一个更有效的方法来改善中风后的结果。
A limited amount of functional recovery commonly occurs in the weeks and months after stroke, and a number of studies show that such recovery is associated with changes in the brain's functional organization. Measures that augment this reorganization in a safe and effective way may therefore help improve outcome in stroke patients. Here we review some of the evidence for functional and anatomical reorganization under normal physiological conditions, along with strategies that augment these processes and improve outcome after brain injury in animal models. These strategies include counteracting inhibitors of axon growth associated with myelin, activating neurons' intrinsic growth state, enhancing physiological activity, and behavioral therapy. These approaches represent a marked departure from the recent focus on neuroprotection and may provide a more effective way to improve outcome after stroke.
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影响因子：
16.2
作者：
Conner, JM;Chiba, AA;Tuszynski, MH
通讯作者：
Tuszynski, MH
影响因子：
5.3
作者：
Brus-Ramer, Marcel;Carmel, Jason B.;Martin, John H.
通讯作者：
Martin, John H.
影响因子：
8.3
作者：
Del Zoppo GJ;Saver JL;Jauch EC;Adams HP Jr;American Heart Association Stroke Council
通讯作者：
American Heart Association Stroke Council
影响因子：
8.3
作者：
Brown, Craig E.;Wong, Charles;Murphy, Timothy H.
通讯作者：
Murphy, Timothy H.
影响因子：
5.7
作者：
Calautti, C;Leroy, F;Baron, JC
通讯作者：
Baron, JC