Antioxidant sol-gel improves cutaneous wound healing in streptozotocin-induced diabetic rats.
Antioxidant sol-gel improves cutaneous wound healing in streptozotocin-induced diabetic rats.
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DOI：
10.1155/2012/504693
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发表时间：
2012
影响因子：
--
通讯作者：
Chien HF
中科院分区：
文献类型：
--
作者：
Lee YH;Chang JJ;Chien CT;Yang MC;Chien HF
我们研究了Pluronic F127中维生素C对糖尿病伤口愈合的影响。建立正常和糖尿病大鼠皮肤全层切除创面模型，观察生理盐水、生理盐水+维生素C(抗氧化剂溶胶)、Pluronic F127或Pluronic F127+维生素C(抗氧化剂溶胶-凝胶)对创面愈合的影响。测定创面收缩率、表皮和真皮成熟度、创面组织胶原合成和细胞凋亡率。体外实验结果表明，在空气中暴露6小时后，对 −、H_2O_2、H_2O_2的清除能力大小顺序为：抗氧化剂Sol-Gel>；抗氧化剂生理盐水>；Pluronic F127=生理盐水。在创伤后7天和14天，抗氧化剂溶胶-凝胶通过加速表皮和真皮的成熟，增加胶原含量，减少细胞凋亡的形成，显著促进伤口的愈合。所有治疗组的创面均在3周内基本愈合。Pluronic F127中的维生素C通过良好的药物输送系统，通过其抗氧化和抗细胞凋亡机制加速皮肤伤口愈合。这项研究表明，Pluronic F127和维生素C可以作为一种新型的伤口愈合促进剂。
We examined the effects of vitamin C in Pluronic F127 on diabetic wound healing. Full-thickness excision skin wounds were made in normal and diabetic Wistar rats to evaluate the effect of saline, saline plus vitamin C (antioxidant sol), Pluronic F127, or Pluronic F127 plus vitamin C (antioxidant sol-gel). The rate of wound contraction, the levels of epidermal and dermal maturation, collagen synthesis, and apoptosis production in the wound tissue were determined. In vitro data showed that after 6 hours of air exposure, the order of the scavenging abilities for HOCl, H2O2, and O2 − was antioxidant sol-gel > antioxidant saline > Pluronic F127 = saline. After 7 and 14 days of wound injury, the antioxidant sol-gel improved wound healing significantly by accelerated epidermal and dermal maturation, an increase in collagen content, and a decrease in apoptosis formation. However, the wounds of all treatments healed mostly at 3 weeks. Vitamin C in Pluronic F127 hastened cutaneous wound healing by its antioxidant and antiapoptotic mechanisms through a good drug delivery system. This study showed that Pluronic F127 plus vitamin C could potentially be employed as a novel wound-healing enhancer.
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影响因子：
5.4
作者：
Khalil, Enam A.;Afifi, Fatma U.;Al-Hussaini, Maysa
通讯作者：
Al-Hussaini, Maysa
影响因子：
14
作者：
Gopinath, D;Ahmed, MR;Jayakumar, R
通讯作者：
Jayakumar, R
影响因子：
4.9
作者：
Oh, SH;Kim, JK;Lee, JH
通讯作者：
Lee, JH
影响因子：
7.7
作者：
Al-Mashat, HA;Kandru, S;Graves, DT
通讯作者：
Graves, DT
影响因子：
4.2
作者：
Bercea, Maria;Darie, Raluca Nicoleta;Morariu, Simona
通讯作者：
Morariu, Simona