Interferon epsilon and preterm birth subtypes; a new piece of the type I interferon puzzle during pregnancy?
Interferon epsilon and preterm birth subtypes; a new piece of the type I interferon puzzle during pregnancy?
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DOI：
10.1111/aji.13526
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发表时间：
2022-04
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干扰素ε (IFNε) 是一种独特的 I 型干扰素，在性类固醇反应中表达。研究表明，I 型干扰素可调节炎症诱发的早产 (PTB)，但尚无研究探讨 IFNε 在人类妊娠中的作用。我们使用来自预防早产和死产全球联盟 (GAPPS) 生物库的妊娠 8-26 周期间储存的阴道拭子，并通过 ELISA 测量 IFNε。总共包括 29 名自发性早产妇女、34 名有医学指征的早产妇女和 134 名足月产妇女。次要结局包括伴有绒毛膜羊膜炎的早产和伴有早产的先兆子痫。 Logistic 回归计算了比值比 (OR) 和 95% 置信区间 (CI)，并根据母亲年龄、种族、体重指数、既往妊娠并发症、下生殖道感染、慢性健康状况和抽血胎龄进行调整。 IFNε 与自发性早产（ORadj 1.0，95% CI 0.7-1.3）或绒毛膜羊膜炎（ORadj 1.6，95% CI 0.7-3.5）之间没有显着相关性。观察到医学上指示的早产几率增加的趋势（ORadj. 1.3，95% CI 1.0-1.8）。这可能是由于患有早产先兆子痫的女性中 IFNε 升高所致（ORadj. 1.9，95% CI 1.2-3.2）。虽然是探索性的，但我们的新发现表明，可能有必要对人类妊娠期间的 IFNε 进行更大规模的纵向研究。
Interferon epsilon (IFNε) is a unique type I IFN that is expressed in response to sex steroids. Studies suggest that type I IFNs regulate inflammation-induced preterm birth (PTB), but no study has examined the role of IFNε in human pregnancy. We used stored vaginal swabs between 8–26 weeks of gestation from the Global Alliance to Prevent Prematurity and Stillbirth (GAPPS) biobank and measured IFNε by ELISA. A total of 29 women with spontaneous preterm births, 34 women with medically indicated preterm births and 134 women with term births were included. Secondary outcomes included a preterm birth with chorioamnionitis and preeclampsia with a preterm birth. Logistic regression calculated odds ratios (OR) and 95% confidence intervals (CI) adjusting for maternal age, race, body mass index, prior pregnancy complications, lower genital tract infections, chronic health conditions, and gestational age at blood draw. There was no significant association between IFNε and spontaneous preterm birth (ORadj 1.0, 95% CI 0.7–1.3) or chorioamnionitis (ORadj 1.6, 95% CI 0.7–3.5). A trend towards increased odds of medically indicated preterm birth (ORadj. 1.3, 95% CI 1.0–1.8) was observed. This was likely due to elevated IFNε among women with preterm preeclampsia (ORadj. 1.9, 95% CI 1.2–3.2). While exploratory, our novel findings suggest that larger longitudinal studies of IFNε across human pregnancy may be warranted.
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DOI：
10.1111/j.1600-0897.2010.00817.x
发表时间：
2010-07-01
期刊：
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影响因子：
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作者：
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通讯作者：
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影响因子：
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发表时间：
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期刊：
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10.1073/pnas.0901329106
发表时间：
2009-06-02
影响因子：
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作者：
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