Immune cells in term and preterm labor.
Immune cells in term and preterm labor.
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DOI：
10.1038/cmi.2014.46
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发表时间：
2014-11
影响因子：
24.1
通讯作者：
中科院分区：
文献类型：
--
作者：
分娩类似于炎症反应，包括由驻留和浸润免疫细胞分泌细胞因子/趋化因子进入生殖组织和母体/胎儿界面。这些炎症通路的不适时激活导致早产，这可能导致早产。早产是新生儿死亡率和发病率的一个主要决定因素，因此，在细胞和分子水平上阐明分娩过程对于理解早产的病理生理学至关重要。在这里，我们总结了先天性和适应性免疫细胞在生理或病理激活劳动的作用。我们回顾了已发表的文献中关于先天性和适应性免疫细胞在子宫颈，子宫肌层，胎膜，蜕膜和胎儿在妊娠晚期和足月及早产分娩中的作用。越来越多的证据表明，先天性免疫细胞（中性粒细胞，巨噬细胞和肥大细胞）介导的过程中释放促炎因子，如细胞因子，趋化因子和基质金属蛋白酶的劳动。适应性免疫细胞（T细胞亚群和B细胞）参与维持妊娠期母胎耐受，其功能或丰度的改变可能导致足月或早产。此外，连接先天性和适应性免疫系统的免疫细胞（自然杀伤T（NKT）细胞和树突状细胞（DC））似乎参与了早产的病理生理学。总之，先天免疫细胞和适应性免疫细胞之间的平衡是维持妊娠所必需的;这种平衡的改变将导致足月或早产。
Labor resembles an inflammatory response that includes secretion of cytokines/chemokines by resident and infiltrating immune cells into reproductive tissues and the maternal/fetal interface. Untimely activation of these inflammatory pathways leads to preterm labor, which can result in preterm birth. Preterm birth is a major determinant of neonatal mortality and morbidity; therefore, the elucidation of the process of labor at a cellular and molecular level is essential for understanding the pathophysiology of preterm labor. Here, we summarize the role of innate and adaptive immune cells in the physiological or pathological activation of labor. We review published literature regarding the role of innate and adaptive immune cells in the cervix, myometrium, fetal membranes, decidua and the fetus in late pregnancy and labor at term and preterm. Accumulating evidence suggests that innate immune cells (neutrophils, macrophages and mast cells) mediate the process of labor by releasing pro-inflammatory factors such as cytokines, chemokines and matrix metalloproteinases. Adaptive immune cells (T-cell subsets and B cells) participate in the maintenance of fetomaternal tolerance during pregnancy, and an alteration in their function or abundance may lead to labor at term or preterm. Also, immune cells that bridge the innate and adaptive immune systems (natural killer T (NKT) cells and dendritic cells (DCs)) seem to participate in the pathophysiology of preterm labor. In conclusion, a balance between innate and adaptive immune cells is required in order to sustain pregnancy; an alteration of this balance will lead to labor at term or preterm.
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影响因子：
3.4
作者：
BHAT, NM;MITHAL, A;TENG, NNH
通讯作者：
TENG, NNH
DOI：
10.1073/pnas.0511025103
发表时间：
2006-03-21
影响因子：
11.1
作者：
Boyson, JE;Nagarkatti, N;Strominger, JL
通讯作者：
Strominger, JL
影响因子：
15.3
作者：
BEER, AE;SCOTT, JR;BILLINGHAM, RE
通讯作者：
BILLINGHAM, RE
影响因子：
9.8
作者：
Bytautiene, E;Vedernikov, YP;Garfield, RE
通讯作者：
Garfield, RE
影响因子：
3.4
作者：
Bosquiazzo, VL;Durando, M;Luque, EH
通讯作者：
Luque, EH