Gamma oscillations during episodic memory processing provide evidence for functional specialization in the longitudinal axis of the human hippocampus.
Gamma oscillations during episodic memory processing provide evidence for functional specialization in the longitudinal axis of the human hippocampus.
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DOI：
10.1002/hipo.23016
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发表时间：
2019-03
期刊：
影响因子：
3.5
通讯作者：
Lega B
中科院分区：
文献类型：
--
作者：
Lin JJ;Umbach G;Rugg MD;Lega B
关于前海马和后海马在情景记忆处理中是否发挥不同或互补的功能作用的问题，在啮齿动物实验和人类非侵入性研究中得到了值得注意的发现。研究人员已经综合这些数据来假设几种功能专业化的模型，然而，这个问题还没有使用直接的大脑记录进行详细探讨。我们最近发表的证据表明，在人类的后海马体中，情景记忆编码过程中θ波功率增加。在我们目前的研究中，我们分析了32例癫痫患者的扩展数据集，这些患者接受了立体EEG癫痫发作映射手术，电极同时精确定位于前海马和后海马，并进行了情景记忆任务。使用重复测量设计，我们寻找编码与检索伽马振荡功率和前与后海马位置的差异之间的相互作用。我们的研究结果是一致的最近铰接模型（HERNET模型）有利于后海马激活检索相关的处理过程中。我们还测试了编码与检索的差异，在首选的伽马频带（高与低伽马振荡）的动机公布的啮齿动物数据。
The question of whether the anterior and posterior hippocampus serve different or complementary functional roles during episodic memory processing has been motivated by noteworthy findings in rodent experiments and from noninvasive studies in humans. Researchers have synthesized these data to postulate several models of functional specialization, However, the issue has not been explored in detail using direct brain recordings. We recently published evidence that theta power increases during episodic memory encoding occur in the posterior hippocampus in humans. In our current investigation we analyzed an expanded data set of 32 epilepsy patients undergoing stereo EEG seizure mapping surgery with electrodes precisely targeted to the anterior and posterior hippocampus simultaneously who performed an episodic memory task. Using a repeated measures design, we looked for an interaction between encoding versus retrieval differences in gamma oscillatory power and anterior versus posterior hippocampal location. Our findings are consistent with a recently articulated model (the HERNET model) favoring posterior hippocampal activation during retrieval related processing. We also tested for encoding versus retrieval differences in the preferred gamma frequency band (high versus low gamma oscillations) motivated by published rodent data.
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