Biaxial response of ovine spinal cord dura mater.
Biaxial response of ovine spinal cord dura mater.
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DOI：
10.1016/j.jmbbm.2014.02.014
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发表时间：
2014-06
影响因子：
3.9
通讯作者：
Puttlitz, Christian M.
中科院分区：
文献类型：
--
作者：
Shetye, Snehal S.;Deault, Matthew M.;Puttlitz, Christian M.
硬脑膜在脊髓复合体的稳定性和机械反应中发挥着重要的功能作用。研究脊髓损伤病因的计算技术需要对硬脑膜进行准确的机械描述。先前研究硬脑膜机械响应的研究报告了关于硬脑膜纵向和周向各向异性刚度的相互矛盾的结果。本研究的目的是研究硬脑膜的双轴响应，以便建立生理负荷情况下的组织水平机械行为。为此，在全面的单轴和双轴加载协议下，在定制的双轴装置中测试了硬脑膜的方形部分。所得数据通过横向各向同性连续体模型和各向异性连续体本构模型进行拟合。横向各向同性公式无法准确预测硬脑膜的单轴行为。各向异性公式准确地预测了纵向和周向的单轴响应。与纵向相比，在圆周方向观察到显着更高的刚度 (p < 0.0001)。此外，与圆周方向相比，纵向显示出明显较低程度的非线性（p < 0.045）和明显较高程度的胶原纤维分散度（p < 0.032）。结果表明，硬脑膜在纵向和周向上具有不同的机械响应，未来的研究应利用各向异性的两纤维族连续体模型来准确描述硬脑膜力学。
The dura mater performs a major functional role in the stability and mechanical response of the spinal cord complex. Computational techniques investigating the etiology of spinal cord injury require an accurate mechanical description of the dura mater. Previous studies investigating the mechanical response of the dura mater have reported conflicting results regarding the anisotropic stiffness of the dura in the longitudinal and circumferential direction. The aim of this study was to investigate the biaxial response of the dura mater in order to establish the tissue level mechanical behavior under physiological loading scenarios. To this end, square sections of the dura were tested in a custom biaxial setup under a comprehensive uniaxial and biaxial loading protocol. The resultant data were fit via a transversely isotropic continuum model and an anisotropic continuum constitutive model. The transversely isotropic formulation failed to accurately predict the dura mater’s uniaxial behavior. The anisotropic formulation accurately predicted the uniaxial response in both longitudinal and circumferential directions. Significantly higher stiffness (p < 0.0001) was observed in the circumferential direction as compared to the longitudinal direction. Further, the longitudinal direction displayed a significantly lower degree of nonlinearity (p < 0.045) and significantly higher degree of collagen fiber dispersion (p < 0.032) as compared to the circumferential direction. Results indicate that the dura mater has differential mechanical response in the longitudinal and circumferential directions and future studies should utilize an anisotropic two fiber family continuum model to accurately describe dura mater mechanics.
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影响因子：
2.4
作者：
McGilvray, Kirk C.;Sarkar, Rajabrata;Puttlitz, Christian M.
通讯作者：
Puttlitz, Christian M.
影响因子：
4.2
作者：
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影响因子：
5.7
作者：
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通讯作者：
Contro, R
DOI：
10.1115/1.4007632
发表时间：
2012-10-01
影响因子：
1.7
作者：
Ayturk, Ugur M.;Gadomski, Benjamin;Puttlitz, Christian M.
通讯作者：
Puttlitz, Christian M.
影响因子：
2.4
作者：
Kroeker, Shannon G.;Morley, Philip L.;Cripton, Peter A.
通讯作者：
Cripton, Peter A.