Distinct sensory representations of wind and near-field sound in the Drosophila brain.
Distinct sensory representations of wind and near-field sound in the Drosophila brain.
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DOI：
10.1038/nature07843
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发表时间：
2009-03-12
期刊：
影响因子：
64.8
通讯作者：
Anderson, David J.
中科院分区：
文献类型：
--
作者：
Yorozu, Suzuko;Wong, Allan;Fischer, Brian J.;Dankert, Heiko;Kernan, Maurice J.;Kamikouchi, Azusa;Ito, Kei;Anderson, David J.
对风的行为反应被认为在控制野生果蝇物种的扩散和种群遗传学以及它们在飞行中的导航方面起着关键作用，但其潜在的神经生物学基础尚不清楚。我们发现，果蝇，像野生捕获的果蝇品系，表现出强大的风诱导的运动抑制（WISL），在自然界中通常遇到的速度提供的气流。在这里，我们确定风敏感的神经元在约翰斯顿的器官（JO），触角mechanosensory结构以前牵连在近场声音检测（审查）。使用Gal4线针对不同的JO神经元的子集，和遗传编码的钙指标，我们表明，风和近场的声音（求爱歌）激活不同的群体JO神经元，这项目的触角和mechanosensory运动中心（AMMC）在中枢脑的不同区域。选择性基因消融风敏感的JO神经元在天线废除WISL行为，而不损害听力。此外，风敏感人群中的不同神经元亚群对气流引起的不同方向的Arista偏转做出反应，并投射到AMMC的不同区域，从而提供了大脑中风向的基本地图。重要的是，声音和风敏感的JO神经元表现出不同的内在响应特性：前者是相位激活的小，双向，位移的aristae，而后者是紧张性激活的单向，静态偏转较大的幅度。这些不同的固有特性非常适合于分别检测近场声和层流气流的振荡脉冲。这些数据确定了JO中的风敏感神经元，JO是一种主要与听力相关的结构，并揭示了大脑如何使用共同的感觉器官区分不同类型的空气颗粒运动。
Behavioral responses to wind are thought to play a critical role in controlling the dispersal and population genetics of wild Drosophila species, as well as their navigation in flight, but their underlying neurobiological basis is unknown. We show that Drosophila melanogaster, like wild-caught Drosophila strains, exhibits robust wind-induced suppression of locomotion (WISL), in response to air currents delivered at speeds normally encountered in nature. Here we identify wind-sensitive neurons in Johnston’s Organ (JO), an antennal mechanosensory structure previously implicated in near-field sound detection (reviewed in). Using Gal4 lines targeted to different subsets of JO neurons, and a genetically encoded calcium indicator, we show that wind and near-field sound (courtship song) activate distinct populations of JO neurons, which project to different regions of the antennal and mechanosensory motor center (AMMC) in the central brain. Selective genetic ablation of wind-sensitive JO neurons in the antenna abolishes WISL behavior, without impairing hearing. Different neuronal subsets within the wind-sensitive population, moreover, respond to different directions of arista deflection caused by airflow and project to different regions of the AMMC, providing a rudimentary map of wind-direction in the brain. Importantly, sound- and wind-sensitive JO neurons exhibit different intrinsic response properties: the former are phasically activated by small, bi-directional, displacements of the aristae, while the latter are tonically activated by unidirectional, static deflections of larger magnitude. These different intrinsic properties are well suited to the detection of oscillatory pulses of near-field sound and laminar airflow, respectively. These data identify wind-sensitive neurons in JO, a structure that has been primarily associated with hearing, and reveal how the brain can distinguish different types of air particle movements, using a common sensory organ.
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影响因子：
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