Comparative genome sequence analysis underscores mycoparasitism as the ancestral life style of Trichoderma.
Comparative genome sequence analysis underscores mycoparasitism as the ancestral life style of Trichoderma.
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DOI：
10.1186/gb-2011-12-4-r40
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发表时间：
2011
期刊：
影响因子：
12.3
通讯作者：
Grigoriev IV
中科院分区：
文献类型：
--
作者：
Kubicek CP;Herrera-Estrella A;Seidl-Seiboth V;Martinez DA;Druzhinina IS;Thon M;Zeilinger S;Casas-Flores S;Horwitz BA;Mukherjee PK;Mukherjee M;Kredics L;Alcaraz LD;Aerts A;Antal Z;Atanasova L;Cervantes-Badillo MG;Challacombe J;Chertkov O;McCluskey K;Coulpier F;Deshpande N;von Döhren H;Ebbole DJ;Esquivel-Naranjo EU;Fekete E;Flipphi M;Glaser F;Gómez-Rodríguez EY;Gruber S;Han C;Henrissat B;Hermosa R;Hernández-Oñate M;Karaffa L;Kosti I;Le Crom S;Lindquist E;Lucas S;Lübeck M;Lübeck PS;Margeot A;Metz B;Misra M;Nevalainen H;Omann M;Packer N;Perrone G;Uresti-Rivera EE;Salamov A;Schmoll M;Seiboth B;Shapiro H;Sukno S;Tamayo-Ramos JA;Tisch D;Wiest A;Wilkinson HH;Zhang M;Coutinho PM;Kenerley CM;Monte E;Baker SE;Grigoriev IV
真菌寄生是一种真菌寄生在另一种真菌上的生活方式，当猎物是植物病原体时具有特殊的相关性，为植物保护提供了生物防治害虫的策略。可能，研究最多的生物防治剂是肉座菌属/木霉属的物种。在这里，我们报告的基因组序列的两个生物控制种深绿木霉（真型肉座菌atroviridis）和绿木霉（原粘帚霉绿，真型肉座菌）的分析，并与里氏木霉（真型肉座菌jecorina）的比较。这三种木霉菌的基因序列保守性很高（78 ~ 96%），缺乏活性移动的元件，可能是由于重复点突变所致。在两种真菌寄生虫中，相对于T. reesei或其它子囊菌，并且在非同线基因组区域中过度表达。系统发育分析表明，T. reesei和T.病毒是相对于T.阿托品。因此，真菌寄生特异性基因出现在一个共同的木霉祖先，但随后在T。reesei。这些数据提供了对真菌寄生的更好理解，从而加强了改进的生物防治菌株的开发，以有效和环境友好地保护植物。
Mycoparasitism, a lifestyle where one fungus is parasitic on another fungus, has special relevance when the prey is a plant pathogen, providing a strategy for biological control of pests for plant protection. Probably, the most studied biocontrol agents are species of the genus Hypocrea/Trichoderma. Here we report an analysis of the genome sequences of the two biocontrol species Trichoderma atroviride (teleomorph Hypocrea atroviridis) and Trichoderma virens (formerly Gliocladium virens, teleomorph Hypocrea virens), and a comparison with Trichoderma reesei (teleomorph Hypocrea jecorina). These three Trichoderma species display a remarkable conservation of gene order (78 to 96%), and a lack of active mobile elements probably due to repeat-induced point mutation. Several gene families are expanded in the two mycoparasitic species relative to T. reesei or other ascomycetes, and are overrepresented in non-syntenic genome regions. A phylogenetic analysis shows that T. reesei and T. virens are derived relative to T. atroviride. The mycoparasitism-specific genes thus arose in a common Trichoderma ancestor but were subsequently lost in T. reesei. The data offer a better understanding of mycoparasitism, and thus enforce the development of improved biocontrol strains for efficient and environmentally friendly protection of plants.
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影响因子：
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通讯作者：
Durbin, R
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