Stromal mast cells in invasive breast cancer are a marker of favourable prognosis: a study of 4,444 cases.
Stromal mast cells in invasive breast cancer are a marker of favourable prognosis: a study of 4,444 cases.
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DOI：
10.1007/s10549-007-9546-3
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发表时间：
2008-01
影响因子：
3.8
通讯作者：
Huntsman, David G.
中科院分区：
文献类型：
--
作者：
Rajput, Ashish B.;Turbin, Dmitry A.;Cheang, Maggie C. U.;Voduc, David K.;Leung, Sam;Gelmon, Karen A.;Gilks, C. Blake;Huntsman, David G.
我们先前在348例浸润性乳腺癌的初步研究中证实，原发性乳腺癌中肥大细胞（MC）浸润与良好预后相关。我们的目的是在更大的浸润性乳腺癌患者队列中验证这一发现，并检查MC的存在与其他临床和病理特征之间的关系。构建包含4，444例病例的临床注释组织微阵列（TMA），并使用标准免疫过氧化物酶技术用c-Kit（CD-117）染色以鉴定和定量MC。对于统计分析，我们应用了分裂样本验证技术。采用Kaplan-Meier [KM]法分析乳腺癌特异性生存率，采用对数秩检验比较生存曲线。KM法生存分析显示，在训练集（P = 0.001）和验证集（P = 0.006）中，间质MC的存在是一个有利的预后因素。生成的X-图来定义MC的最佳数量，显示任何数量的间质MC的存在预示着良好的预后。多因素分析表明，在训练集中，（风险比[HR] = 0.804，95%置信区间[CI]，0.653-0.991，P = 0.041）和验证集分析（HR = 0.846，95%CI，0.683-1.049，P = 0.128）与年龄、肿瘤分级、肿瘤大小、淋巴结、ER和Her 2状态无关。这项研究的结论是，浸润性乳腺癌中的间质MC浸润是一个独立的良好预后标志物，并重申了局部炎症反应在乳腺癌进展中的关键作用。
We have previously demonstrated in a pilot study of 348 invasive breast cancers that mast cell (MC) infiltrates within primary breast cancers are associated with a good prognosis. Our aim was to verify this finding in a larger cohort of invasive breast cancer patients and examine the relationship between the presence of MCs and other clinical and pathological features. Clinically annotated tissue microarrays (TMAs) containing 4,444 cases were constructed and stained with c-Kit (CD-117) using standard immunoperoxidase techniques to identify and quantify MCs. For statistical analysis, we applied a split-sample validation technique. Breast cancer specific survival was analyzed by Kaplan–Meier [KM] method and log rank test was used to compare survival curves. Survival analysis by KM method showed that the presence of stromal MCs was a favourable prognostic factor in the training set (P = 0.001), and the validation set group (P = 0.006). X-tile plot generated to define the optimal number of MCs showed that the presence of any number of stromal MCs predicted good prognosis. Multivariate analysis showed that the MC effect in the training set (Hazard ratio [HR] = 0.804, 95% Confidence interval [CI], 0.653–0.991, P = 0.041) and validation set analysis (HR = 0.846, 95% CI, 0.683–1.049, P = 0.128) was independent of age, tumor grade, tumor size, lymph node, ER and Her2 status. This study concludes that stromal MC infiltration in invasive breast cancer is an independent good prognostic marker and reiterates the critical role of local inflammatory responses in breast cancer progression.
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影响因子：
24.3
作者：
Imada, A;Shijubo, N;Abe, S
通讯作者：
Abe, S
DOI：
10.1161/01.atv.0000051405.68811.4d
发表时间：
2003-02-01
影响因子：
8.7
作者：
Leskinen, MJ;Lindstedt, KA;Kovanen, PT
通讯作者：
Kovanen, PT
影响因子：
7.5
作者：
Caruso, RA;Bellocco, R;Inferrera, C
通讯作者：
Inferrera, C
影响因子：
4.3
作者：
FARRAM, E;NELSON, DS
通讯作者：
NELSON, DS
影响因子：
3.9
作者：
LACHTER, J;STEIN, M;MUNICHOR, M
通讯作者：
MUNICHOR, M