Enhanced Place Specificity of the Parallel Auditory Brainstem Response: A Modeling Study.
Enhanced Place Specificity of the Parallel Auditory Brainstem Response: A Modeling Study.
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DOI：
10.1177/23312165231205719
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发表时间：
2023-01
影响因子：
2.7
通讯作者：
Maddox, Ross K.
中科院分区：
文献类型：
--
作者：
Stoll, Thomas J.;Maddox, Ross K.
关键词：
虽然耳蜗上的每个地方对特定频率最敏感，但它通常会对广泛频率范围内的足够高水平的刺激做出反应。在诊断性听觉脑干反应（ABR）检查期间，这种激励的扩散可能在临床阈值估计中引入误差。可以通过向测试刺激添加掩蔽噪声来减轻离频耳蜗激励，但是引入掩蔽器增加了典型ABR测试已经很长的测试时间。我们的实验室最近开发了并行ABR（pABR）该范例通过利用随机刺激定时来同时估计多个频率的阈值来加快测试时间。有理由相信多个频率的平行呈现提供了掩蔽效应，并在减少测试时间的同时提高了位置特异性。在这里，我们使用两个计算模型的听觉周边的特点预测效果的平行演示的位置特异性在听神经。我们还研究了刺激率和水平的影响。这两种模型都表明pABR至少与标准方法一样具有位置特异性，在高水平下，特别是在高刺激率下，平行呈现（与串行相比）的位置特异性有所改善。当在其中一个模型中模拟听力损伤时，位置特异性在阈值附近也得到了改善。这种改进的位置特异性将代表pABR更快的测试时间的次要益处，而不是权衡。
While each place on the cochlea is most sensitive to a specific frequency, it will generally respond to a sufficiently high-level stimulus over a wide range of frequencies. This spread of excitation can introduce errors in clinical threshold estimation during a diagnostic auditory brainstem response (ABR) exam. Off-frequency cochlear excitation can be mitigated through the addition of masking noise to the test stimuli, but introducing a masker increases the already long test times of the typical ABR exam. Our lab has recently developed the parallel ABR (pABR) paradigm to speed up test times by utilizing randomized stimulus timing to estimate the thresholds for multiple frequencies simultaneously. There is reason to believe parallel presentation of multiple frequencies provides masking effects and improves place specificity while decreasing test times. Here, we use two computational models of the auditory periphery to characterize the predicted effect of parallel presentation on place specificity in the auditory nerve. We additionally examine the effect of stimulus rate and level. Both models show the pABR is at least as place specific as standard methods, with an improvement in place specificity for parallel presentation (vs. serial) at high levels, especially at high stimulus rates. When simulating hearing impairment in one of the models, place specificity was also improved near threshold. Rather than a tradeoff, this improved place specificity would represent a secondary benefit to the pABR's faster test times.
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