Geographic social vulnerability is associated with the alpha diversity of the human microbiome.
Geographic social vulnerability is associated with the alpha diversity of the human microbiome.
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DOI：
10.1128/msystems.01308-22
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发表时间：
2023-10-26
期刊：
影响因子：
6.4
通讯作者：
中科院分区：
文献类型：
--
作者：
生活在人体内的人类微生物群生态系统暴露于来自人类生活的各种环境的外源性外来物质。因此，微生物与人类宿主之间的动态可能受到环境变化的影响，这可能会影响微生物组的组成和多样性。地理区域作为与微生物相关的环境因素，已被广泛报道。然而，人文地理通常与社会经济地位、种族和民族人口飞地以及地区劣势的差异联系在一起。将微生物群与地区不利因素联系起来的潜在机制包括家庭拥挤、公共交通的使用以及缺乏对生物多样性自然环境的接触。通过分析来自人类微生物组计划的数据，包括在微生物组采样时报告居住地信息的健康成年人（n = 201），我们发现，在控制年龄、性别和体重指数的情况下，社会脆弱性指数（SVI）（作为区域劣势的衡量标准）与口腔、气道和泌尿生殖器部位的多重α多样性指标之间存在显著关系。在种族/民族方面，我们发现SVI评分对解释女性泌尿生殖微生物多样性的种族/民族差异具有显著的中介作用。我们的研究结果强调了将环境变量（如区域社会脆弱性）作为健康个体微生物组研究中感兴趣的变量的重要性，并提出了解释泌尿生殖种族/民族差异的潜在作用。未来的研究需要包括多样化、代表性的以社区为基础的人群，更精确的居住地点，并纳入相关的风险因素，如饮食摄入，以进一步了解这些结果的含义。作为与微生物组相关疾病的风险因素，了解SVI对微生物组多样性的作用可能有助于确定微生物组研究对公共卫生的影响。在这里，我们发现，使用人类微生物组计划第一阶段队列的子样本，SVI与跨身体部位的微生物组多样性有关，并且SVI可能影响基于种族/民族的多样性差异。我们的研究结果建立在当前关于人类地理学在微生物组研究中的作用的知识基础上，表明在探索微生物组α多样性时，地理社会脆弱性的测量可被视为额外的背景因素。
The human microbiome ecosystems living within the human body are exposed to exogenous foreign substances from the various environments that humans live within. Therefore, dynamics between microbes and human hosts can be influenced by environmental changes, which potentially impact microbiome composition and diversity. Geographic area, as a microbiome-relevant environmental factor, has been well reported. Human geography, however, is often linked to socioeconomic status, racial and ethnic population enclaves, and disparities in area disadvantage. Potential mechanisms linking the microbiome to factors tied to area disadvantage include household crowding, use of public transportation, and lack of exposure to biodiverse natural environments. Through an analysis of data from the Human Microbiome Project including healthy adults who reported residential area information at the time of microbiome sampling (n = 201), we found a significant relationship between the social vulnerability index (SVI), as a measure of area disadvantage, and multiple alpha diversity measures across oral, airways, and urogenital sites when controlling for age, gender, and body mass index. With regard to race/ethnicity, we found significant mediation by SVI score to explain racial/ethnic differences in urogenital microbiome diversity in females. Our results highlight the importance of considering environmental variables such as area social vulnerability as a variable of interest in microbiome studies within healthy individuals and suggest a potential role to explain urogenital race/ethnicity differences. Future studies including a diverse, representative community-based population, more precise residential location, and inclusion of related risk factors such as dietary intake, are needed to further understand the implications of these results. As a risk factor for conditions related to the microbiome, understanding the role of SVI on microbiome diversity may assist in identifying public health implications for microbiome research. Here we found, using a sub-sample of the Human Microbiome Project phase 1 cohort, that SVI was linked to microbiome diversity across body sites and that SVI may influence race/ethnicity-based differences in diversity. Our findings, build on the current knowledge regarding the role of human geography in microbiome research, suggest that measures of geographic social vulnerability be considered as additional contextual factors when exploring microbiome alpha diversity.
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影响因子：
15.9
作者：
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