Omicron extensively but incompletely escapes Pfizer BNT162b2 neutralization.
Omicron extensively but incompletely escapes Pfizer BNT162b2 neutralization.
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DOI：
10.1038/s41586-021-04387-1
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发表时间：
2022-03
期刊：
影响因子：
64.8
通讯作者：
Sigal A
中科院分区：
文献类型：
--
作者：
Cele S;Jackson L;Khoury DS;Khan K;Moyo-Gwete T;Tegally H;San JE;Cromer D;Scheepers C;Amoako DG;Karim F;Bernstein M;Lustig G;Archary D;Smith M;Ganga Y;Jule Z;Reedoy K;Hwa SH;Giandhari J;Blackburn JM;Gosnell BI;Abdool Karim SS;Hanekom W;NGS-SA;COMMIT-KZN Team;von Gottberg A;Bhiman JN;Lessells RJ;Moosa MS;Davenport MP;de Oliveira T;Moore PL;Sigal A
令人担忧的SARS-CoV-2变种Omicron（Pango谱系www.example.com）的出现首先在博茨瓦纳和南非发现，可能会损害疫苗的有效性并导致再次感染。在这里，我们研究了Omicron逃避与辉瑞BNT162b2疫苗接种的南非个体的抗体中和。我们使用了接种疫苗后不久采集的血液样本，这些血液样本来自接种疫苗并曾感染过SARS-CoV-2或接种疫苗但无既往感染证据的个体。我们从感染者中分离并测序确认了活Omicron病毒，并观察到Omicron需要血管紧张素转换酶2（ACE2）受体来感染细胞。我们比较了Omicron相对于祖先SARS-CoV-2毒株的血浆中和作用，发现与仅接种疫苗的参与者相比，感染和接种疫苗的个体对祖先病毒的中和作用要高得多。然而，两组均显示疫苗引起的Omicron变异体中和作用降低了22倍，接种疫苗且先前感染过的参与者显示出的Omicron残留中和作用与仅接种疫苗组中观察到的祖先病毒中和作用水平相似。这些数据支持这样的观点，即使用疫苗接种方法可以维持对Omicron的合理保护。来自接种BNT 162 b2的个体的血浆显示出对Omicron（B.1.1.529）的中和能力比对祖先SARS-CoV-2毒株的中和能力低22倍，但在具有高水平的祖先病毒中和的那些个体中保持了残余中和。
The emergence of the SARS-CoV-2 variant of concern Omicron (Pango lineage B.1.1.529), first identified in Botswana and South Africa, may compromise vaccine effectiveness and lead to re-infections. Here we investigated Omicron escape from neutralization by antibodies from South African individuals vaccinated with Pfizer BNT162b2. We used blood samples taken soon after vaccination from individuals who were vaccinated and previously infected with SARS-CoV-2 or vaccinated with no evidence of previous infection. We isolated and sequence-confirmed live Omicron virus from an infected person and observed that Omicron requires the angiotensin-converting enzyme 2 (ACE2) receptor to infect cells. We compared plasma neutralization of Omicron relative to an ancestral SARS-CoV-2 strain and found that neutralization of ancestral virus was much higher in infected and vaccinated individuals compared with the vaccinated-only participants. However, both groups showed a 22-fold reduction in vaccine-elicited neutralization by the Omicron variant. Participants who were vaccinated and had previously been infected exhibited residual neutralization of Omicron similar to the level of neutralization of the ancestral virus observed in the vaccination-only group. These data support the notion that reasonable protection against Omicron may be maintained using vaccination approaches. Plasma from individuals vaccinated with BNT162b2 exhibits 22-fold less neutralization capacity against Omicron (B.1.1.529) than against an ancestral SARS-CoV-2 strain but residual neutralization is maintained in those with high levels of neutralization of ancestral virus.
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影响因子：
82.9
作者：
Ebinger JE;Fert-Bober J;Printsev I;Wu M;Sun N;Prostko JC;Frias EC;Stewart JL;Van Eyk JE;Braun JG;Cheng S;Sobhani K
通讯作者：
Sobhani K
影响因子：
7.7
作者：
Weisblum Y;Schmidt F;Zhang F;DaSilva J;Poston D;Lorenzi JC;Muecksch F;Rutkowska M;Hoffmann HH;Michailidis E;Gaebler C;Agudelo M;Cho A;Wang Z;Gazumyan A;Cipolla M;Luchsinger L;Hillyer CD;Caskey M;Robbiani DF;Rice CM;Nussenzweig MC;Hatziioannou T;Bieniasz PD
通讯作者：
Bieniasz PD
影响因子：
30.3
作者：
Keeton R;Richardson SI;Moyo-Gwete T;Hermanus T;Tincho MB;Benede N;Manamela NP;Baguma R;Makhado Z;Ngomti A;Motlou T;Mennen M;Chinhoyi L;Skelem S;Maboreke H;Doolabh D;Iranzadeh A;Otter AD;Brooks T;Noursadeghi M;Moon JC;Grifoni A;Weiskopf D;Sette A;Blackburn J;Hsiao NY;Williamson C;Riou C;Goga A;Garrett N;Bekker LG;Gray G;Ntusi NAB;Moore PL;Burgers WA
通讯作者：
Burgers WA
DOI：
10.1056/nejmoa2108891
发表时间：
2021-08-12
期刊：
The New England journal of medicine
影响因子：
--
作者：
Lopez Bernal J;Andrews N;Gower C;Gallagher E;Simmons R;Thelwall S;Stowe J;Tessier E;Groves N;Dabrera G;Myers R;Campbell CNJ;Amirthalingam G;Edmunds M;Zambon M;Brown KE;Hopkins S;Chand M;Ramsay M
通讯作者：
Ramsay M
DOI：
10.1016/s2666-5247(21)00267-6
发表时间：
2022-01
期刊：
The Lancet. Microbe
影响因子：
--
作者：
Cromer D;Steain M;Reynaldi A;Schlub TE;Wheatley AK;Juno JA;Kent SJ;Triccas JA;Khoury DS;Davenport MP
通讯作者：
Davenport MP