Associations of Early to Mid-Childhood Adiposity with Elevated Mid-Childhood Alanine Aminotransferase Levels in the Project Viva Cohort.
Associations of Early to Mid-Childhood Adiposity with Elevated Mid-Childhood Alanine Aminotransferase Levels in the Project Viva Cohort.
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DOI：
10.1016/j.jpeds.2018.01.069
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发表时间：
2018-06
期刊：
影响因子：
--
通讯作者：
Taveras EM
中科院分区：
文献类型：
--
作者：
Woo Baidal JA;Elbel EE;Lavine JE;Rifas-Shiman SL;Gillman MW;Oken E;Taveras EM
To examine the longitudinal relationship of early to mid-childhood adiposity measures with mid-childhood alanine aminotransferase (ALT) levels. We studied 635 children in the Project Viva cohort. Research staff measured weight, height, skinfolds thicknesses, and waist and hip circumferences at early (median 3.2 years) and mid-childhood (median 7.7 years) visits. At mid-childhood, we collected blood for ALT analysis. We used established sex-specific ALT cut-offs to define elevated ALT. In multivariable linear and logistic regression models, we assessed the association of adiposity measures from early to mid-childhood with mid-childhood ALT level, adjusting for confounders. Children were 48% female, 59% white, 21% black, 6% Hispanic/Latino, and 3% Asian. At early childhood, 29% had overweight/obesity and mean waist circumference was 51.5 (SD 3.8) cm. At mid-childhood, mean ALT was 20.3 (SD 7.3) units/liter and 23% had an elevated ALT. In multivariable-adjusted regression models, each additional 10 centimeters greater waist circumference at early childhood was associated with 1.99 (95% CI: 1.19, 3.33) higher odds of elevated ALT at mid-childhood. Greater increases from early to mid-childhood in BMI z-score, sum of subscapular and triceps skinfold thicknesses, waist circumference, and hip circumference were associated with higher ALT at mid-childhood. In this prospective cohort, higher waist circumference at early childhood and greater increases in adiposity measures from early to mid-childhood were associated with higher ALT levels at mid-childhood.
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影响因子：
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作者：
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DOI：
10.1002/hep.28283
发表时间：
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期刊：
Hepatology (Baltimore, Md.)
影响因子：
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通讯作者：
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