Utility of waist-to-height ratio in assessing the status of central obesity and related cardiometabolic risk profile among normal weight and overweight/obese children: the Bogalusa Heart Study.
Utility of waist-to-height ratio in assessing the status of central obesity and related cardiometabolic risk profile among normal weight and overweight/obese children: the Bogalusa Heart Study.
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DOI：
10.1186/1471-2431-10-73
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发表时间：
2010-10-11
期刊：
影响因子：
2.4
通讯作者：
Berenson GS
中科院分区：
文献类型：
--
作者：
Mokha JS;Srinivasan SR;Dasmahapatra P;Fernandez C;Chen W;Xu J;Berenson GS
身体质量指数（BMI）被广泛用于评估肥胖对儿童心脏代谢风险的影响，但它并不总是与中心性肥胖相关，并随生长和成熟而变化。腰高比（WHtR）是一个相对恒定的腹部肥胖的人体测量指标，在不同的年龄，性别或种族群体。然而，在正常体重和超重/肥胖儿童中，根据公认的BMI阈值分类，关于WHtR在评估腹部肥胖状态和相关心脏代谢风险特征方面的效用的信息很少。采用了3091名4-18岁黑人和白色儿童（56%白色，50%男性）的横断面心脏代谢危险因素变量。根据BMI的年龄、种族和性别特征，将儿童分为正常体重（第5 - 85百分位数）和超重/肥胖（≥ 85百分位数）。根据WHtR（<0.5，无中心性肥胖vs ≥ 0.5，中心性肥胖）比较各组的风险特征。正常体重组9.2%的儿童为中心性肥胖（WHtR ≥0.5），超重/肥胖组19.8%的儿童为非中心性肥胖（WHtR < 0.5）。在多变量分析中，体重正常的中心性肥胖儿童的LDL胆固醇、HDL胆固醇、甘油三酯和胰岛素水平分别是正常儿童的1.66、2.01、1.47和2.05倍。除了父母有较高的2型糖尿病病史外，体重正常的中心性肥胖组的代谢综合征患病率也明显较高（p < 0.0001）。在超重/肥胖组中，与中心性肥胖组相比，无中心性肥胖组HDL胆固醇和HOMA-IR显著不良水平的可能性分别低0.53和0.27倍（p < 0.05）。这些无中心性肥胖的超重/肥胖儿童的父母高血压（p = 0.002）、2型糖尿病（p = 0.03）和代谢综合征（p < 0.0001）病史的患病率也明显较低。WHtR不仅可以检测正常体重儿童中的中心性肥胖和相关的不良心脏代谢风险，而且可以识别超重/肥胖儿童中没有这些情况的儿童，这对儿科初级保健实践具有意义。
Body Mass Index (BMI) is widely used to assess the impact of obesity on cardiometabolic risk in children but it does not always relate to central obesity and varies with growth and maturation. Waist-to-Height Ratio (WHtR) is a relatively constant anthropometric index of abdominal obesity across different age, sex or racial groups. However, information is scant on the utility of WHtR in assessing the status of abdominal obesity and related cardiometabolic risk profile among normal weight and overweight/obese children, categorized according to the accepted BMI threshold values. Cross-sectional cardiometabolic risk factor variables on 3091 black and white children (56% white, 50% male), 4-18 years of age were used. Based on the age-, race- and sex-specific percentiles of BMI, the children were classified as normal weight (5th - 85th percentiles) and overweight/obese (≥ 85th percentile). The risk profiles of each group based on the WHtR (<0.5, no central obesity versus ≥ 0.5, central obesity) were compared. 9.2% of the children in the normal weight group were centrally obese (WHtR ≥0.5) and 19.8% among the overweight/obese were not (WHtR < 0.5). On multivariate analysis the normal weight centrally obese children were 1.66, 2.01, 1.47 and 2.05 times more likely to have significant adverse levels of LDL cholesterol, HDL cholesterol, triglycerides and insulin, respectively. In addition to having a higher prevalence of parental history of type 2 diabetes mellitus, the normal weight central obesity group showed a significantly higher prevalence of metabolic syndrome (p < 0.0001). In the overweight/obese group, those without central obesity were 0.53 and 0.27 times less likely to have significant adverse levels of HDL cholesterol and HOMA-IR, respectively (p < 0.05), as compared to those with central obesity. These overweight/obese children without central obesity also showed significantly lower prevalence of parental history of hypertension (p = 0.002), type 2 diabetes mellitus (p = 0.03) and metabolic syndrome (p < 0.0001). WHtR not only detects central obesity and related adverse cardiometabolic risk among normal weight children, but also identifies those without such conditions among the overweight/obese children, which has implications for pediatric primary care practice.
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影响因子：
2.8
作者：
Srinivasan, Sathanur R.;Wang, Ren;Berenson, Gerald S.
通讯作者：
Berenson, Gerald S.
影响因子：
5.1
作者：
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Muto, T
影响因子：
4.9
作者：
Bosy-Westphal, A;Geisler, C;Müller, MJ
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Müller, MJ
影响因子：
5.1
作者：
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通讯作者：
Glueck, Charles J.
影响因子：
5.2
作者：
Hall, DMB;Cole, TJ
通讯作者：
Cole, TJ