Exacerbation of tonic but not phasic pain by entorhinal cortex lesions
Exacerbation of tonic but not phasic pain by entorhinal cortex lesions
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内嗅皮质病变导致强直性疼痛加剧，但阶段性疼痛不加剧
DOI：
10.1016/j.neulet.2014.05.015
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发表时间：
2014-10
影响因子：
2.5
通讯作者：
Yi Ming
中科院分区：
文献类型：
--
作者：
Zhang Yu;Liu Feng-Yu;Wan You;Yi Ming
海马体积极参与疼痛调节。以往的研究表明，抑制、切除或药物干预海马或其皮质下传入源，如内侧隔和杏仁核，产生抗伤害性作用。但是海马体的皮层连接如何调节疼痛仍然没有被探索。内嗅皮层（EC）构成海马和新皮层之间的主要通道。在本研究中，大鼠内侧（MEC），外侧（LEC）或假EC损伤，并接受热板和足底福尔马林注射试验。MEC和LEC病变均不影响热板试验和福尔马林试验的第一阶段。相比之下，在福尔马林试验的第二阶段中，MEC和LEC病变的舔爪反应显著增加。这些结果表明，由EC引导的海马-皮层相互作用参与强直性疼痛而不是阶段性疼痛，并且海马的皮层和皮层下连接在疼痛调制中发挥独立的作用。
The hippocampus is actively involved in pain modulation. Previous studies have shown that inhibition, resection or pharmacological interference of the hippocampus or its subcortical afferent sources such as the medial septum and amygdala produce anti-nociceptive effects. But how the cortical connections of the hippocampus modulate pain remains unexplored. The entorhinal cortex (EC) constitutes the major gateway between the hippocampus and the neocortex. In the present study, rats with medial (MEC), lateral (LEC) or sham EC lesions and received the hot plate and the intra-plantar formalin injection tests. Neither MEC nor LEC lesions affected the hot plate test and the first phase of the formalin test. In contrast, paw licking responses in the second phase of the formalin test significantly increased with both MEC and LEC lesions. These results suggested that that the hippocampal–cortical interactions channeled by the EC were involved in tonic but not phasic pain conditions, and that cortical and sub-cortical connections of the hippocampus played independent roles in pain modulation.
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影响因子：
3.4
作者：
Naber, PA;Witter, MP;da Silva, FHL
通讯作者：
da Silva, FHL
影响因子：
4.1
作者：
A. Gol;G. Faibish
通讯作者：
A. Gol;G. Faibish
DOI：
10.1523/jneurosci.0587-12.2012
发表时间：
2012-04-25
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Mutso AA;Radzicki D;Baliki MN;Huang L;Banisadr G;Centeno MV;Radulovic J;Martina M;Miller RJ;Apkarian AV
通讯作者：
Apkarian AV
影响因子：
2.9
作者：
Hebert, MA;Ardid, D;Blanchard, RJ
通讯作者：
Blanchard, RJ
影响因子：
5
作者：
Erfanparast, Amir;Tamaddonfard, Esmaeal;Khalilzadeh, Emad
通讯作者：
Khalilzadeh, Emad