Choroidal and Retinal Abnormalities by Optical Coherence Tomography in Endogenous Cushing's Syndrome.
Choroidal and Retinal Abnormalities by Optical Coherence Tomography in Endogenous Cushing's Syndrome.
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DOI：
10.3389/fendo.2016.00154
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发表时间：
2016
影响因子：
5.2
通讯作者：
Fragoso MC
中科院分区：
文献类型：
--
作者：
Abalem MF;Machado MC;Santos HN;Garcia R;Helal J Jr;Carricondo PC;Pimentel SL;Monteiro ML;Qian CX;Bronstein MD;Fragoso MC
皮质醇被认为是脉络膜增厚的危险因素，这可能导致视网膜改变。比较内源性活动性库欣综合征（CS）患者使用光学相干断层扫描（OCT）测量的脉络膜厚度，并评估同一组患者视网膜异常的发生。横断面研究。门诊诊所。11例女性CS患者处于高皮质醇状态，通过24小时尿皮质醇、低剂量地塞米松抑制试验未抑制皮质醇和夜间唾液皮质醇水平的至少两项异常测量来确定。使用oct评估脉络膜和视网膜形态，脉络膜厚度测量和视网膜变化的存在。CS组的平均中央凹下巩膜厚度为372.96±73.14µm，对照组为255.63±50.70µm （p < 0.001）。1例（9.09%）表现为中心性浆液性脉络膜视网膜病变，1例（9.09%）表现为厚脉络膜色素上皮病变。与健康和匹配对照相比，活动性CS患者的眼睛脉络膜厚度增加。此外，18.18%的患者出现黄斑病变，可能继发于脉络膜增厚。虽然需要进一步的研究来证实我们的发现，但过量的皮质类固醇水平似乎对脉络膜有显著影响，并可能与继发性视网膜疾病有关。
Cortisol has been suggested as a risk factor for choroidal thickening, which may lead to retinal changes. To compare choroidal thickness measurements using optical coherence tomography (OCT) in patients with endogenous active Cushing’s syndrome (CS) and to evaluate the occurrence of retinal abnormalities in the same group of patients. Cross-sectional study. Outpatient clinic. Eleven female patients with CS in hypercortisolism state as determined by the presence of at least two abnormal measurements from urinary cortisol 24 h, no suppression of cortisol with low dose dexamethasone suppression test, and nocturnal salivary cortisol levels and 12 healthy controls. Choroidal and retinal morphology was assessed using OCT. Choroidal thickness measurements and the presence of retinal changes. The mean subfoveal choroidal thickness was 372.96 ± 73.14 µm in the patients with CS and 255.63 ± 50.70 µm in the control group (p < 0.001). One patient (9.09%) presented with central serous chorioretinopathy and one patient (9.09%) with pachychoroid pigment epitheliopathy. Choroidal thickness is increased in the eyes of patients with active CS compared to healthy and matched control. Also, 18.18% of patients presented with macular changes, possibly secondary to choroidal thickening. While further studies are necessary to confirm our findings, excess corticosteroid levels seem to have a significant effect on the choroid and might be associated with secondary retinal diseases.
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影响因子：
13.7
作者：
Branchini LA;Adhi M;Regatieri CV;Nandakumar N;Liu JJ;Laver N;Fujimoto JG;Duker JS
通讯作者：
Duker JS
影响因子：
17.8
作者：
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Wallman, Josh
DOI：
10.1097/iae.0b013e3181be0a83
发表时间：
2009-11-01
影响因子：
3.3
作者：
Imamura, Yutaka;Fujiwara, Takamitsu;Spaide, Richard F.
通讯作者：
Spaide, Richard F.
DOI：
10.1097/iae.0000000000001198
发表时间：
2017-03-01
影响因子：
3.3
作者：
Karaca, Cagatay;Karaca, Zuleyha;Mirza, Galip Ertugrul
通讯作者：
Mirza, Galip Ertugrul
影响因子：
5.8
作者：
Feelders, Richard A.;Hofland, Leo J.
通讯作者：
Hofland, Leo J.