Analysis of choroidal morphologic features and vasculature in healthy eyes using spectral-domain optical coherence tomography.
Analysis of choroidal morphologic features and vasculature in healthy eyes using spectral-domain optical coherence tomography.
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DOI：
10.1016/j.ophtha.2013.01.066
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发表时间：
2013-09
期刊：
影响因子：
13.7
通讯作者：
Duker JS
中科院分区：
文献类型：
--
作者：
Branchini LA;Adhi M;Regatieri CV;Nandakumar N;Liu JJ;Laver N;Fujimoto JG;Duker JS
目的：应用频域光学相干断层扫描（SD-OCT）技术对正常人眼脉络膜的形态和血管结构进行分析。横断面回顾性审查。2009年11月至2010年9月期间，在马萨诸塞州波士顿的新英格兰眼科中心使用Cirrus HD-OCT进行高清扫描的42例健康受试者（42只眼），无眼部疾病。评价SD-OCT图像的脉络膜形态学特征，包括脉络膜-巩膜边界的形状、脉络膜最厚点的位置和局灶性脉络膜变薄的区域。总脉络膜厚度和脉络膜大血管层厚度由两名独立的观察者使用Cirrus线性测量工具在中心凹（距中心凹鼻侧和颞侧750μm）处测量，这两名观察者在分析OCT图像方面经验丰富。使用定制软件计算脉络膜基质与脉络膜血管腔的比率。脉络膜形态学的定性评估、脉络膜血管系统的定量分析以及使用新型自动化软件来确定脉络膜基质面积与脉络膜血管腔面积的比率。42例受试者的平均年龄为51.6岁。所有受试者（100%）的脉络膜-巩膜交界处呈“碗状”或凸状，88.0%的受试者脉络膜最厚点位于中心凹下方。脉络膜厚度平均为256.8±75.8μm，其中大血管层厚度为204.3±65.9μm，中血管层/脉络膜毛细血管层厚度为52.9±20.6μm。脉络膜大血管层厚度与脉络膜总厚度的比值为0.7±0.06。软件生成的脉络膜基质面积与脉络膜血管腔面积的比率为0.27±0.08，表明在健康眼睛中脉络膜血管腔形成比脉络膜基质更大比例的脉络膜。这是第一个研究描述脉络膜的形态和血管系统在健康的眼睛从1行光栅扫描获得使用SD-OCT的方法描述持有承诺，并在识别脉络膜形态的微妙变化和脉络膜血管病变在各种疾病状态的作用，在未来可能会通知新的治疗方式的直接临床效用。
To analyze the morphology and vasculature of the choroid in healthy eyes using spectral-domain optical coherence tomography (SD-OCT). Cross-sectional retrospective review. Forty-two healthy subjects (42 eyes), with no ocular disease who underwent high-definition scanning with Cirrus HD-OCT at the New England Eye Center, Boston, Massachusetts between November 2009 and September 2010. The SD-OCT images were evaluated for morphological features of the choroid, including the shape of the choroid-scleral border, location of the thickest point of choroid and regions of focal choroidal thinning. Total choroidal thickness and large choroidal vessel layer thickness were measured by two independent observers experienced in analyzing OCT images using the Cirrus linear measurement tool at the fovea, 750μm nasal and temporal to the fovea. Custom software was used to calculate the ratio of choroidal stroma to the choroidal vessel lumen. Qualitative assessment of the choroidal morphology, quantitative analysis of choroidal vasculature and use of a novel automated software to determine the ratio of choroidal stromal area to the area of choroidal vessel lumen. The 42 subjects had a mean age of 51.6 years. All subjects (100%) had a “bowl” or convex shape to the choroid-sclera junction and the thickest point of the choroid was under the fovea in 88.0% of the subjects. The mean choroidal thickness was 256.8±75.8μm, thickness of the large choroidal vessel layer was 204.3±65.9μm and that of medium choroidal vessel layer/choriocapillaris layer was 52.9±20.6μm beneath the fovea. The ratio of large choroidal vessel layer thickness to the total choroidal thickness beneath the fovea was 0.7±0.06. The software generated ratio of choroidal stromal area to the choroidal vessel lumen area to be 0.27±0.08, suggesting that choroidal vessel lumen forms a greater proportion of the choroid than choroidal stroma in healthy eyes. This is the first study describing the morphology and vasculature of choroid in healthy eyes from 1-line raster scans obtained using SD-OCT. The method described holds promise, and has immediate clinical utility in recognizing subtle changes in choroidal morphology and the role of choroidal angiopathy in various disease states, that in the future might inform new treatment modalities.
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影响因子：
3.7
作者：
Sohrab M;Wu K;Fawzi AA
通讯作者：
Fawzi AA
DOI：
10.1097/iae.0b013e3181be0a83
发表时间：
2009-11-01
影响因子：
3.3
作者：
Imamura, Yutaka;Fujiwara, Takamitsu;Spaide, Richard F.
通讯作者：
Spaide, Richard F.
影响因子：
3.8
作者：
White, BR;Pierce, MC;de Boer, JF
通讯作者：
de Boer, JF
影响因子：
13.7
作者：
Bressler, Neil M.
通讯作者：
Bressler, Neil M.
DOI：
10.1007/s00417-011-1620-1
发表时间：
2011-08-01
影响因子：
2.7
作者：
Koizumi, Hideki;Yamagishi, Tetsuya;Kinoshita, Shigeru
通讯作者：
Kinoshita, Shigeru