Diet, microbiota, and dysbiosis: a 'recipe' for colorectal cancer.
Diet, microbiota, and dysbiosis: a 'recipe' for colorectal cancer.
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饮食，微生物群和营养不良：结直肠癌的“食谱”。
DOI：
10.1039/c5fo01276g
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发表时间：
2016-04
期刊：
影响因子：
6.1
通讯作者：
O'Keefe SJ
中科院分区：
文献类型：
--
作者：
Vipperla K;O'Keefe SJ
我们所吃的食物不仅养活了我们自己，也养活了我们胃肠道内庞大而多样的微生物群。在一个共生共同进化的过程中，肠道微生物群对维持我们结肠的健康和完整性至关重要。近年来，新一代DNA测序技术和代谢谱的出现，揭示了微生物多样性和功能的显著复杂性，微生物群产生各种各样的生物活性产物，这些产物不仅在粘膜表面活跃，而且在全身被吸收和循环，影响远处器官的健康和功能。因此，已经确定了几种微生物群组成模式及其与健康和疾病状态的关联。重要的是，被称为生态失调的微生物-宿主关系受到干扰，现在被认为是包括结直肠癌（CRC）在内的越来越多疾病的根本原因。越来越多的体外和体内证据表明，饮食对微生物群组成的选择以及饮食的几种健康促进和有害作用实际上是由微生物群介导的。最近的研究发现，膳食纤维可以促进结肠微生物合成抗增殖和抗癌代谢物，特别是丁酸盐，这强调了饮食调整作为遏制结直肠癌流行的关键措施的先决条件。更好地了解饮食与微生物群的相互作用，并进行大规模研究，以评估饮食调整和肠道微生物群调节在逆转生态失调和恢复健康方面的功效，可能为预防和/或治疗西化疾病提供新的策略，这些疾病目前被认为是对公众健康的主要威胁。
The food we consume feeds not only us, but also a vast and diverse community of microbiota within our gastrointestinal tract. In a process of symbiotic co-evolution, the gut microbiota became essential for the maintenance of the health and integrity of our colon. The advent of next-generation DNA sequencing technology and metabolic profiling have, in the recent years, revealed the remarkable complexity of microbial diversity and function, and that the microbiota produce a wide variety of bioactive products that are not only active at the mucosal surface, but also absorbed and circulated throughout the body, influencing distant organ health and function. As a result, several microbiota compositional patterns and their associations with both health and disease states have been identified. Importantly, a disturbed micro-biota–host relationship, termed dysbiosis, is now recognized to be the root cause for a growing list of diseases, including colorectal cancer (CRC). There is mounting in vitro and in vivo evidence to suggest that diet selects for the microbiota composition and several health promoting and deleterious effects of diet are, in fact, mediated by the microbiota. Recent findings of the feasibility of dietary fiber to boost the colonic microbial synthesis of anti-proliferative and counter carcinogenic metabolites, particularly butyrate, underscores the prerequisite of dietary modification as a key measure to curb the pandemic of CRC in westernized countries. Better understanding of the diet–microbiota interplay and large-scale studies to evaluate the efficacy of dietary modification and gut microbiota modulation in reversing dysbiosis and restoring health could offer novel preventative and/or therapeutic strategies against westernized diseases, which are now considered the chief threat to public health.
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影响因子：
--
作者：
Biagi, Elena;Candela, Marco;Fairweather-Tait, Susan;Franceschi, Claudio;Brigidi, Patrizia
通讯作者：
Brigidi, Patrizia
影响因子：
6.1
作者：
Bernstein, Carol;Holubec, Hana;Bhattacharyya, Achyut K.;Huy Nguyen;Payne, Claire M.;Zaitlin, Beryl;Bernstein, Harris
通讯作者：
Bernstein, Harris
影响因子：
3.7
作者：
Claesson MJ;O'Sullivan O;Wang Q;Nikkilä J;Marchesi JR;Smidt H;de Vos WM;Ross RP;O'Toole PW
通讯作者：
O'Toole PW
影响因子：
64.8
作者：
Devkota, Suzanne;Wang, Yunwei;Musch, Mark W.;Leone, Vanessa;Fehlner-Peach, Hannah;Nadimpalli, Anuradha;Antonopoulos, Dionysios A.;Jabri, Bana;Chang, Eugene B.
通讯作者：
Chang, Eugene B.
影响因子：
64.8
作者：
Arumugam, Manimozhiyan;Raes, Jeroen;Pelletier, Eric;Le Paslier, Denis;Yamada, Takuji;Mende, Daniel R.;Fernandes, Gabriel R.;Tap, Julien;Bruls, Thomas;Batto, Jean-Michel;Bertalan, Marcelo;Borruel, Natalia;Casellas, Francesc;Fernandez, Leyden;Gautier, Laurent;Hansen, Torben;Hattori, Masahira;Hayashi, Tetsuya;Kleerebezem, Michiel;Kurokawa, Ken;Leclerc, Marion;Levenez, Florence;Manichanh, Chaysavanh;Nielsen, H. Bjorn;Nielsen, Trine;Pons, Nicolas;Poulain, Julie;Qin, Junjie;Sicheritz-Ponten, Thomas;Tims, Sebastian;Torrents, David;Ugarte, Edgardo;Zoetendal, Erwin G.;Wang, Jun;Guarner, Francisco;Pedersen, Oluf;de Vos, Willem M.;Brunak, Soren;Dore, Joel;Weissenbach, Jean;Ehrlich, S. Dusko;Bork, Peer
通讯作者：
Bork, Peer