Aging of the human metaorganism: the microbial counterpart.
Aging of the human metaorganism: the microbial counterpart.
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DOI：
10.1007/s11357-011-9217-5
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发表时间：
2012-02
期刊：
影响因子：
--
通讯作者：
Brigidi, Patrizia
中科院分区：
文献类型：
--
作者：
Biagi, Elena;Candela, Marco;Fairweather-Tait, Susan;Franceschi, Claudio;Brigidi, Patrizia
由于与肠道菌群有着密切的共生关系，人类最近被视为“元生物”。这一假设对衰老过程提出了更全面的看法，其中必须考虑到环境，肠道微生物群和宿主之间相互作用的动态。胃肠道中与年龄相关的生理变化，以及生活方式、营养行为和宿主免疫系统功能的改变，不可避免地影响肠道微生物生态系统。在这里，我们回顾了目前对老年人肠道微生物群变化的了解，特别是根据现代分子表征技术的最新应用。与年龄相关的肠道微生物群失衡在炎症老化和免疫衰老过程中的假设参与也将被讨论。越来越多的证据表明肠道微生物群稳态对宿主健康的重要性，这促使人们考虑通过开发针对老年人的益生菌和益生元制剂来将这一知识应用于医学/营养领域。报告在老年人典型临床条件下使用益生元/益生元的少数干预试验的结果将被严格审查。
Human beings have been recently reviewed as ‘metaorganisms’ as a result of a close symbiotic relationship with the intestinal microbiota. This assumption imposes a more holistic view of the ageing process where dynamics of the interaction between environment, intestinal microbiota and host must be taken into consideration. Age-related physiological changes in the gastrointestinal tract, as well as modification in lifestyle, nutritional behaviour, and functionality of the host immune system, inevitably affect the gut microbial ecosystem. Here we review the current knowledge of the changes occurring in the gut microbiota of old people, especially in the light of the most recent applications of the modern molecular characterisation techniques. The hypothetical involvement of the age-related gut microbiota unbalances in the inflamm-aging, and immunosenescence processes will also be discussed. Increasing evidence of the importance of the gut microbiota homeostasis for the host health has led to the consideration of medical/nutritional applications of this knowledge through the development of probiotic and prebiotic preparations specific for the aged population. The results of the few intervention trials reporting the use of pro/prebiotics in clinical conditions typical of the elderly will be critically reviewed.
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影响因子：
3.7
作者：
Biagi E;Nylund L;Candela M;Ostan R;Bucci L;Pini E;Nikkïla J;Monti D;Satokari R;Franceschi C;Brigidi P;De Vos W
通讯作者：
De Vos W
影响因子：
168.9
作者：
Christensen, Kaare;Doblhammer, Gabriele;Rau, Roland;Vaupel, James W.
通讯作者：
Vaupel, James W.
影响因子：
3.7
作者：
Claesson MJ;O'Sullivan O;Wang Q;Nikkilä J;Marchesi JR;Smidt H;de Vos WM;Ross RP;O'Toole PW
通讯作者：
O'Toole PW
四个星期的短链果糖摄入摄入导致健康的老年志愿者的粪便双歧杆菌和胆固醇排泄增加。
影响因子：
5.4
作者：
Bouhnik Y;Achour L;Paineau D;Riottot M;Attar A;Bornet F
通讯作者：
Bornet F
影响因子：
3.7
作者：
Andersson, Anders F.;Lindberg, Mathilda;Jakobsson, Hedvig;Backhed, Fredrik;Nyren, Pal;Engstrand, Lars
通讯作者：
Engstrand, Lars