Nanoparticle-based theranostic agents.
Nanoparticle-based theranostic agents.
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DOI：
10.1016/j.addr.2010.07.009
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发表时间：
2010-08-30
影响因子：
16.1
通讯作者：
Chen, Xiaoyuan
中科院分区：
文献类型：
--
作者：
Xie, Jin;Lee, Seulki;Chen, Xiaoyuan
关键词：
治疗诊断纳米医学正在成为一个有前途的治疗范例。它利用纳米平台的高容量来运送货物并将成像和治疗功能加载到它们上。由此产生的纳米系统，能够诊断，药物输送和监测治疗反应，预计将在个性化医疗的曙光时代发挥重要作用，并已致力于这一目标的研究工作。构建这种功能整合剂的便利性在于许多纳米平台本身已经是成像剂。它们发达的表面化学使得它们很容易装载药物并将其提升为治疗诊断纳米系统。氧化铁纳米颗粒、量子点、碳纳米管、金纳米颗粒和二氧化硅纳米颗粒先前已经在成像环境中得到了很好的研究，并且是用于构建基于纳米颗粒的治疗诊断学的候选纳米平台。在当前的文章中，我们将按照核心材料的类别，概述沿着这条路线的进展。我们将专注于建设战略，并将讨论与这一新兴技术相关的挑战和机遇。
Theranostic nanomedicine is emerging as a promising therapeutic paradigm. It takes advantage of the high capacity of nanoplatforms to ferry cargo and loads onto them both imaging and therapeutic functions. The resulting nanosystems, capable of diagnosis, drug delivery and monitoring of therapeutic response, are expected to play a significant role in the dawning era of personalized medicine, and much research effort has been devoted toward that goal. A convenience in constructing such function-integrated agents is that many nanoplatforms are already, themselves, imaging agents. Their well developed surface chemistry makes it easy to load them with pharmaceutics and promote them to be theranostic nanosystems. Iron oxide nanoparticles, quantum dots, carbon nanotubes, gold nanoparticles and silica nanoparticles, have been previously well investigated in the imaging setting and are candidate nanoplatforms for building up nanoparticle-based theranostics. In the current article, we will outline the progress along this line, organized by the category of the core materials. We will focus on construction strategies and will discuss the challenges and opportunities associated with this emerging technology.
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