Porous hollow Fe(3)O(4) nanoparticles for targeted delivery and controlled release of cisplatin.
Porous hollow Fe(3)O(4) nanoparticles for targeted delivery and controlled release of cisplatin.
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DOI：
10.1021/ja903300f
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发表时间：
2009-08-05
影响因子：
15
通讯作者：
Sun, Shouheng
中科院分区：
文献类型：
--
作者：
Cheng, Kai;Peng, Sheng;Xu, Chenjie;Sun, Shouheng
我们报告了一种新的方法，顺铂的存储和释放使用多孔空心纳米粒子（PHNPs）的Fe 3 O 4。我们通过在250°C下控制Fe NP的氧化，然后进行酸蚀刻来制备PHNP。开孔（~2-4 nm）促进顺铂扩散到中空结构的腔中。多孔壳在中性或碱性生理条件下稳定，顺铂通过相同孔从腔中逃逸是扩散控制的缓慢过程，t1/2 = 16 h。但在低pH（< 6）条件下，孔经受酸性蚀刻，导致更宽的孔间隙和更快的顺铂释放，t1/2 < 4小时。一旦与Herceptin偶联到表面，顺铂负载的中空纳米颗粒可以靶向乳腺癌SK-BR-3细胞，IC 50达到2.9 μM，远低于游离顺铂所需的6.8 μM。我们的模型实验表明，低pH值响应的PHNPs的Fe 3 O 4可以利用作为顺铂的靶向特异性治疗应用的载体。
We report a new approach to cisplatin storage and release using porous hollow nanoparticles (PHNPs) of Fe3O4. We prepared the PHNPs by controlled oxidation of Fe NPs at 250°C followed by acid etching. The opening pores (~2–4 nm) facilitated the cisplatin diffusion into the cavity of the hollow structure. The porous shell was stable in neutral or basic physiological conditions and cisplatin escape from the cavity through the same pores was diffusion-controlled slow process with t1/2 = 16 hrs. But in low pH (< 6) conditions, the pores were subject to acidic etching, resulting in wider pore gaps and faster release of cisplatin with t1/2 < 4 hrs. Once coupled with Herceptin to the surface, the cisplatin-loaded hollow NPs could target to breast cancer SK-BR-3 cells with IC50 reaching 2.9 μM, much lower than 6.8 μM needed for free cisplatin. Our model experiments indicate that the low pH-responsive PHNPs of Fe3O4 can be exploited as a cisplatin delivery vehicle for target-specific therapeutic applications.
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DOI：
10.1002/polb.1986.090240215
发表时间：
1986-02-01
影响因子：
--
作者：
KORSMEYER, RW;VONMEERWALL, E;PEPPAS, NA
通讯作者：
PEPPAS, NA
影响因子：
15
作者：
Mantri, Yogita;Lippard, Stephen J.;Baik, Mu-Hyun
通讯作者：
Baik, Mu-Hyun
影响因子：
10.8
作者：
Nasongkla, Norased;Bey, Erik;Gao, Jinming
通讯作者：
Gao, Jinming
影响因子：
15
作者：
Gao, Jinhao;Liang, Gaolin;Xu, Bing
通讯作者：
Xu, Bing
影响因子：
82.9
作者：
Lee, Jae-Hyun;Huh, Yong-Min;Cheon, Jinwoo
通讯作者：
Cheon, Jinwoo