Low-Grade systemic inflammation is associated with domain-specific cognitive performance and cognitive decline in older adults: Data from the TUDA study
Low-Grade systemic inflammation is associated with domain-specific cognitive performance and cognitive decline in older adults: Data from the TUDA study
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低度全身炎症与老年人特定领域的认知表现和认知能力下降有关：TUDA 研究的数据
DOI：
10.1016/j.neurobiolaging.2023.11.008
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发表时间：
--
影响因子：
4.2
通讯作者：
Dyer A.H.
中科院分区：
文献类型：
--
作者：
Dyer A.H.
研究慢性炎症，认知功能和老年人认知能力下降之间的关系的研究产生了相互矛盾的结果。在一个大型的老年人队列中（n = 3270; 73.1 ± 7.9岁; 68.4%为女性），我们评估了血清细胞因子（IL-6，IL-10，TNF-α）与整体和特定领域认知表现之间的横向和纵向关系（可重复神经心理状态评估组合[RBANS]）。较高的IL-6（OR：1.33; 1.06，1.66，p = 0.01）、TNF-α（OR：1.35; 1.09，1.67，p = 0.01）和IL-6：IL-10比值（OR：1.43; 1.17，1.74，p = 0.001）与总体RBANS表现受损存在横断面相关性。对于特定的认知领域，在较高的TNF-α水平和较差的视觉空间和注意力表现之间观察到最大的效应量。在一个参与者亚组（n = 725; 69.8 ± 5.5岁; 67.0%女性）中，在中位数为5.4年时进行重复评估，只有较高的基线IL-6：IL-10比值与总体事件、即时记忆和视觉空间表现受损相关。女性的关联性更强，但不受年龄或APOE基因型的影响。
Studies examining the relationships between chronic inflammation, cognitive function and cognitive decline in older adults have yielded conflicting results. In a large cohort of older adults free from established dementia (n = 3270; 73.1 ± 7.9 years; 68.4% female), we evaluated the cross-sectional and longitudinal relationships between serum cytokines (IL-6, IL-10, TNF-α) and both global and domain-specific cognitive performance (Repeatable Battery for Assessment of Neuropsychological Status [RBANS]). Higher IL-6 (OR: 1.33; 1.06, 1.66, p = 0.01), TNF-α (OR: 1.35; 1.09, 1.67, p = 0.01) and IL-6:IL-10 Ratio (OR: 1.43; 1.17, 1.74, p = 0.001) were cross-sectionally associated with impaired global RBANS performance. For specific cognitive domains, greatest effect sizes were observed between higher TNF-α levels and poorer visual-spatial and attention performance. In a subset of participants (n = 725; 69.8 ± 5.5 years; 67.0% female) with repeat assessment performed at a median of 5.4 years, only higher baseline IL-6:IL-10 ratio was associated with impaired incident overall, immediate memory and visual-spatial performance. Associations were stronger in females, but not modified by age orAPOEgenotype.
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影响因子：
3.5
作者：
A. Dyer;R. Briggs;E. Laird;L. Hoey;C. Hughes;H. McNulty;M. Ward;J. Strain;A. Molloy;C. Cunningham;K. McCarroll
通讯作者：
A. Dyer;R. Briggs;E. Laird;L. Hoey;C. Hughes;H. McNulty;M. Ward;J. Strain;A. Molloy;C. Cunningham;K. McCarroll
DOI：
10.1016/j.jamda.2018.11.031
发表时间：
2019-05-01
影响因子：
7.6
作者：
Moore, Katie;Hughes, Catherine F.;McNulty, Helene
通讯作者：
McNulty, Helene
DOI：
10.1093/gerona/glu132
发表时间：
2015-07-01
影响因子：
5.1
作者：
Palta, Priya;Xue, Qian-Li;Carlson, Michelle C.
通讯作者：
Carlson, Michelle C.
社区老年人长期使用抗胆碱能药物、苯二氮卓类药物和 Z 药物：对认知和神经心理表现有何影响？
影响因子：
4
作者：
A. Dyer;E. Laird;L. Hoey;C. Hughes;H. McNulty;M. Ward;J. Strain;A. Molloy;C. Cunningham;K. McCarroll
通讯作者：
K. McCarroll
影响因子：
6.3
作者：
Kenny, Rose Anne;Coen, Robert F.;Savva, George M.
通讯作者：
Savva, George M.