Serum antibody responses to Streptococcus mutans antigens in humans systemically infected with oral streptococci.

Serum antibody responses to Streptococcus mutans antigens in humans systemically infected with oral streptococci.
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全身感染口腔链球菌的人体对变形链球菌抗原的血清抗体反应。

DOI:
10.1111/j.1399-302x.1992.tb00630.x
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发表时间:
1992
影响因子:
--
通讯作者:
Henrichsen,J
Henrichsen,J
中科院分区:
--
文献类型:
--
作者:
Russell,MW;Wu,HY;White,PL;Kilian,M;Henrichsen,J

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采用酶联免疫吸附试验检测由变形链球菌或其他口腔链球菌引起的亚急性细菌性心内膜炎(SBE)患者和正常人的血清中抗S抗体。变异抗原变形链球菌-SBE血清中IgG和伊加同种型的Ag I/II和Ag III抗体显著升高,3份血清中的伊加抗体包括聚合体和单体形式。还发现抗脂磷壁酸IgM和IgG以及抗血清型c多糖IgG和伊加抗体升高。6例感染其他口腔链球菌的患者中有4例的血清也显示抗S抗体。突变Ag I/II. 3例患者血清中检出缓症链球菌或口腔链球菌感染,但均未检出。变形杆菌感染的病例中,显示出对人心脏肌膜的抗体升高,并且所有SBE血清都具有升高的类风湿因子。这些结果表明,已知的S.突变体在人类中呈免疫显性,不太可能产生心脏交叉反应。
Sera from patients with subacute bacterial endocarditis (SBE) due toStreptococcus mutansor other oral streptococci and from normal subjects were assayed by enzyme‐linked immunosorbent assay for antibodies to definedS. mutansantigens. Antibodies of IgG and IgA isotypes to Ag I/II and Ag III were greatly elevated inS. mutans‐SBE sera, and the IgA antibodies in 3 sera included both polymeric and monomeric forms. Elevated IgM and IgG anti‐lipoteichoic acid and IgG and IgA anti‐serotype c polysaccharide antibodies were also found. The sera of 4 of 6 patients infected with other oral streptococci also displayed antibodies toS. mutansAg I/II. Sera of 3 patients infected withStreptococcus mitis or Streptococcus orallis.but none of thes. mutans‐infected cases, showed elevated antibodies to human heart sarcolemma, and all SBE sera had elevated rheumatoid factor. These results suggest that the known surface protein antigens ofS. mutansare immunodominant in humans, and are not likely to be heart cross‐reactive.
使用来自变形链球菌的纯化蛋白抗原对恒河猴进行抗龋齿免疫
DOI: 10.1128/iai.34.2.407-415.1981
发表时间: 1981
影响因子: 3.1
作者:
T. Lehner;M. Russell;J. Caldwell;R. Smith
通讯作者: R. Smith
兔抗变形链球菌血清中的心脏反应性抗体不能与变形链球菌发生交叉反应。
DOI: --
发表时间: 1988
期刊: Journal of immunology (Baltimore, Md. : 1950)
影响因子: --
作者:
Swartzwelder,FJ;Barua,PK;Albini,B;Stinson,MW
通讯作者: Stinson,MW
DOI: --
发表时间: 1973
影响因子: 3.2
作者:
A. J. Wicken;J. Gibbens;K. Knox
通讯作者: K. Knox
DOI: --
发表时间: 1977
影响因子: 15.3
作者:
I. V. D. Rijn;JB Sabriskie;M. Mccarty
通讯作者: M. Mccarty
DOI: --
发表时间: 1983
影响因子: 4.8
作者:
B. Maisch;H. Eichstädt;K. Kochsiek
通讯作者: K. Kochsiek