Investigation of the relationship between ocular sarcoidosis and dry eye.
Investigation of the relationship between ocular sarcoidosis and dry eye.
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DOI：
10.1038/s41598-022-07435-6
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发表时间：
2022-03-02
影响因子：
4.6
通讯作者：
Sotozono C
中科院分区：
文献类型：
--
作者：
Aoki T;Yokoi N;Nagata K;Deguchi H;Sekiyama Y;Sotozono C
眼结节病（OcSar）和干眼症（DE）之间的关系先前已有报道。在这里，我们研究了OcSar和其他葡萄膜炎，Vogt-Koyanagi-Harada病（VKH）的泪液功能，以阐明OcSar和DE之间的关联。本研究涉及27例女性OcSar患者的27只眼[平均年龄：67.3 ± 13.5（SD）岁]、18例女性VKH患者的18只眼（53.1 ± 14.1岁）和17例女性健康对照受试者的17只眼（59.7 ± 9.6岁）。分析所有受检眼的泪液半月板高度（TMH，mm）、荧光素破裂时间（FBUT，s）、角膜结膜上皮损伤评分（艾德）和Schirmer 1试验（ST 1，mm/5 min）。在OcSar患者、VKH患者和对照受试者中，各自的TMH、FBUT、艾德和ST 1值（平均值± SD）分别为0.26 ± 0.10、0.24 ± 0.09和0.24 ± 0.08、4.3 ± 2.5、7.3 ± 2.9和6.3 ± 3.1、1.1 ± 1.1、0.7 ± 0.8和0.1 ± 0.3和12.9 ± 10.5，21.5 ± 12.1和24.3 ± 10.5。在统计学上，OcSar患者的ST 1值显著低于VKH患者（P = 0.004）和对照受试者（P = 0.001）。ST 1结果显示，在OcSar病例中，减弱DE中泪膜和眼表上皮之间恶性循环的神经反射弧和泪腺系统显著受损，因此表明OcSar和DE之间可能存在相关性。
A relationship between ocular sarcoidosis (OcSar) and dry eye (DE) has previously been reported. Here we investigated the tear function in OcSar, and the other uveitis, Vogt–Koyanagi–Harada disease (VKH), to elucidate the association between OcSar and DE. This study involved 27 eyes of 27 female OcSar patients [mean age: 67.3 ± 13.5 (SD) years], 18 eyes of 18 female VKH patients (53.1 ± 14.1 years), and 17 eyes of 17 female healthy control subjects (59.7 ± 9.6 years). In all examined eyes, tear meniscus height (TMH, mm), fluorescein breakup time (FBUT, s), scoring of keratoconjunctival epithelial damage (ED), and the Schirmer 1 test (ST1, mm/5 min) were analyzed. In the OcSar patients, VKH patients, and control subjects, the respective TMH, FBUT, ED, and ST1 values (mean ± SD) were 0.26 ± 0.10, 0.24 ± 0.09, and 0.24 ± 0.08, 4.3 ± 2.5, 7.3 ± 2.9, and 6.3 ± 3.1, 1.1 ± 1.1, 0.7 ± 0.8, and 0.1 ± 0.3, and 12.9 ± 10.5, 21.5 ± 12.1, and 24.3 ± 10.5. Statistically, the ST1 values were significantly lower in the OcSar patients than in the VKH patients (P = 0.004) and control subjects (P = 0.001). ST1 findings revealed that the neural reflex arc and lacrimal gland system, which attenuate the vicious cycle between the tear film and ocular surface epithelium in DE, are significantly impaired in OcSar cases, thus indicating a possible association between OcSar and DE.
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DOI：
10.1136/bjo.41.3.153
发表时间：
1957-03-01
期刊：
The British journal of ophthalmology
影响因子：
--
作者：
JONES, B R;STEVENSON, C J
通讯作者：
STEVENSON, C J
DOI：
10.4274/tjo.89310
发表时间：
2017-06-01
影响因子：
1.1
作者：
Kiziltunc, Pinar Bingol;Ciftci, Fatma;Kaygusuz, Gulsah
通讯作者：
Kaygusuz, Gulsah
影响因子：
1
作者：
Serruya, Leão Gabbay;Nogueira, Daniel Cruz;Hida, Richard Yudi
通讯作者：
Hida, Richard Yudi
影响因子：
4.2
作者：
Demirci, Hakan;Christianson, Murray D.
通讯作者：
Christianson, Murray D.
影响因子：
3.4
作者：
Kawasaki, S;Kawamoto, S;Okubo, K
通讯作者：
Okubo, K