Atavisms in the avian hindlimb and early developmental polarity of the limb.

Atavisms in the avian hindlimb and early developmental polarity of the limb.
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鸟类后肢的返祖现象与肢体的早期发育极性。

DOI:
10.1002/dvdy.318
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发表时间:
2021-09
期刊:
Developmental dynamics : an official publication of the American Association of Anatomists
影响因子:
--
通讯作者:
Harris MP
Harris MP
中科院分区:
其他
文献类型:
--
作者:
Bonatto Paese CL;Hawkins MB;Brugmann SA;Harris MP

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自然发生的鸡突变体talpid(ta2),以其肢体和颅面缺陷而闻名,长期以来一直是发育生物学家研究颅面结构和肢体生长和模式的宝贵工具。突变体提供了一个独特的工具来检查调节肢体发育的分子和细胞过程。这种突变体也为发育遗传程序的进化提供了独特的见解。先前的工作定义了ta2胚胎中返祖牙列的出现。本文描述ta2鸡胚后肢祖先性状的出现。由于ta2表型是由于C2CD3突变和纤毛功能破坏而产生的,这种突变体提供了对肢体不对称原因的遗传和发育见解,也是鸟类后肢进化的模型。
The naturally occurring chicken mutant talpid (ta2), best known for its limb and craniofacial defects, has long served as a valuable tool for developmental biologists studying growth and patterning of craniofacial structures and the limb. The mutant provides a unique tool to examine the molecular and cellular processes regulating limb development. This mutant also provides unique insights into the evolution of developmental genetic programs. Previous work defined the appearance of atavistic dentition in ta2 embryos. Herein we describe the appearance of ancestral characters of the hindlimb in embryonic ta2 chicken embryos. As the ta2 phenotype arises as a result of mutation in C2CD3 and disrupted cilia function, this mutant provides genetic and developmental insight into the causes of asymmetry in the limb and also a model for the evolution of the avian hindlimb.
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发表时间: 2020-01-14
影响因子: 11.1
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