Electron Paramagnetic Resonance pO2 Image Tumor Oxygen-Guided Radiation Therapy Optimization.
Electron Paramagnetic Resonance pO2 Image Tumor Oxygen-Guided Radiation Therapy Optimization.
复制标题
电子顺磁共振 pO2 图像肿瘤氧引导放射治疗优化。
DOI：
10.1007/978-3-319-55231-6_39
复制
发表时间：
2017
影响因子：
--
通讯作者：
Halpern,HowardJ
中科院分区：
文献类型：
--
作者：
Epel,Boris;Maggio,Matt;Pelizzari,Charles;Halpern,HowardJ
放射治疗的现代标准不考虑放射治疗计划的肿瘤氧合。肿瘤氧合和放射治疗成功之间的强相关性表明，氧引导放射治疗（OGRT）可能是一种有前途的增强癌症放射治疗。我们已经为啮齿动物开发了OGRT协议。电子顺磁共振（EPR）成像用于记录氧图，具有高空间分辨率和优于1 μ m的优异精度。使用动物调强放射治疗（IMRT）XRAD 225 Cx微型CT/治疗系统进行放射治疗。辐射计划分两步执行。首先，将均匀的15%肿瘤对照剂量（TCD 15）递送至整个肿瘤。在第二步中，将相当于TCD 98和TCD 15之间差异的额外加强剂量递送到耐辐射的缺氧肿瘤区域。使用多端口适形射束协议进行加强剂量的递送。对于辐射束成形，我们使用由钨注入ABS聚合物3D打印的单独辐射块。在氧气成像之后，紧接着EPR成像仪进行射束几何形状的计算和块的产生。初步结果表明，辐射输送的亚毫米精度和高剂量精度。目前正在C3 H小鼠腿部生长的同基因FSa纤维肉瘤肿瘤上测试放射治疗的功效。
Modern standards for radiation treatment do not take into account tumor oxygenation for radiation treatment planning. Strong correlation between tumor oxygenation and radiation treatment success suggests that oxygen-guided radiation therapy (OGRT) may be a promising enhancement of cancer radiation treatment. We have developed an OGRT protocol for rodents. Electron paramagnetic resonance (EPR) imaging is used for recording oxygen maps with high spatial resolution and excellent accuracy better than 1 torr. Radiation is delivered with an animal intensity modulated radiation therapy (IMRT) XRAD225Cx micro-CT/ therapy system. The radiation plan is delivered in two steps. First, a uniform 15% tumor control dose (TCD15) is delivered to the whole tumor. In the second step, an additional booster dose amounting to the difference between TCD98and TCD15is delivered to radio-resistant, hypoxic tumor regions. Delivery of the booster dose is performed using a multiport conformal beam protocol. For radiation beam shaping we used individual radiation blocks 3D-printed from tungsten infused ABS polymer. Calculation of beam geometry and the production of blocks is performed next to the EPR imager, immediately after oxygen imaging. Preliminary results demonstrate the sub-millimeter precision of the radiation delivery and high dose accuracy. The efficacy of the radiation treatment is currently being tested on syngeneic FSa fibrosarcoma tumors grown in the legs of C3H mice.
DOI：
10.1201/9781420034530.ch1
发表时间：
2004-10
期刊：
Nihon rinsho. Japanese journal of clinical medicine
影响因子：
--
作者：
Naoki Nakamura;N. Shikama;Masahiko Oguchi
通讯作者：
Naoki Nakamura;N. Shikama;Masahiko Oguchi
DOI：
10.1039/9781849734837-00180
发表时间：
2013-01-01
期刊：
ELECTRON PARAMAGNETIC RESONANCE, VOL 23
影响因子：
--
作者：
Epel, Boris;Halpern, Howard
通讯作者：
Halpern, Howard
影响因子：
2.5
作者：
Rockwell S;Dobrucki IT;Kim EY;Marrison ST;Vu VT
通讯作者：
Vu VT