Hypoxia and radiation therapy: past history, ongoing research, and future promise.
Hypoxia and radiation therapy: past history, ongoing research, and future promise.
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DOI：
10.2174/156652409788167087
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发表时间：
2009-05
影响因子：
2.5
通讯作者：
Vu VT
中科院分区：
文献类型：
--
作者：
Rockwell S;Dobrucki IT;Kim EY;Marrison ST;Vu VT
肿瘤缺氧影响放疗、化疗甚至手术治疗的结果，不仅对具有广泛坏死的巨大肿瘤的治疗，而且对非常小的原发性肿瘤和复发、微转移以及显微镜下肿瘤累及的手术切缘的治疗。由于低氧肿瘤细胞对辐射和许多抗癌药物具有抗性，因此在实验室研究和临床试验中已经检查了许多规避低氧诱导的治疗抗性的方法。在这篇综述中，这些方法和过去的实验室和临床研究的结果进行了描述和过去的代理商和他们的测试的局限性进行了讨论。我们描述了测量人类肿瘤缺氧的新技术的重要性，这些技术可以评估治疗前肿瘤氧水平和长期治疗方案过程中缺氧的变化。这些提供了改进临床试验设计和选择将受益于低氧定向治疗的患者的可能性，以及促进开发用于低氧定向治疗的更好的药剂和方案的可能性。我们还讨论了如何提高认识的异常血管床在实体瘤和缺氧的影响和相关的微环境的侮辱，从最近和正在进行的研究，提供了潜在的寻找新的治疗靶点，这可能会导致新的药物和新的治疗方法的发展选择性靶向细胞在实体瘤内的不良微环境。
Tumor hypoxia influences the outcome of treatment with radiotherapy, chemotherapy and even surgery, not only for the treatment of large bulky tumors with extensive necrosis, but also in the treatment of very small primary tumors and recurrences, micrometastases, and surgical margins with microscopic tumor involvement. Because hypoxic tumor cells are resistant to radiation and to many anticancer drugs, many approaches to circumventing the therapeutic resistance induced by hypoxia have been examined in laboratory studies and clinical trials. In this review, these approaches and the results of past laboratory and clinical studies are described and the limitations of the past agents and their testing are discussed. We describe the importance of new technologies for measuring hypoxia in human tumors, which allow assessment of pretreatment tumor oxygen levels and changes in hypoxia over the course of prolonged treatment regimens. These offer the possibility of improving the design of clinical trials and the selection of patients who will benefit from hypoxia-directed therapies, as well as the possibility of facilitating the development of better agents and regimens for use in hypoxia-directed therapy. We also discuss how the improved understanding of the abnormal vascular beds in solid tumors and of the effects of hypoxia and related microenvironmental insults, resulting from recent and ongoing research, offers the potential for finding new therapeutic targets, that may lead to the development of new agents and novel therapeutic approaches for selectively targeting cells in the adverse microenvironments within solid tumors.
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DOI：
10.1098/rspb.1933.0044
发表时间：
1933-07-01
期刊：
PROCEEDINGS OF THE ROYAL SOCIETY OF LONDON SERIES B-CONTAINING PAPERS OF A BIOLOGICAL CHARACTER
影响因子：
--
作者：
Crabtree, HG;Cramer, W
通讯作者：
Cramer, W
影响因子：
5.7
作者：
DISCHE, S
通讯作者：
DISCHE, S
影响因子：
2.6
作者：
BROWN, JM
通讯作者：
BROWN, JM
DOI：
10.3109/10731199209119738
发表时间：
1992-01-01
期刊：
BIOMATERIALS ARTIFICIAL CELLS AND IMMOBILIZATION BIOTECHNOLOGY
影响因子：
--
作者：
DOWLING, S;FISCHER, JJ;ROCKWELL, S
通讯作者：
ROCKWELL, S
影响因子：
11.2
作者：
Cao, YT;Li, CY;Dewhirst, MW
通讯作者：
Dewhirst, MW