Elevated Serum Interleukin-23 Levels in Patients with Oral and Cutaneous Lichen Planus.
Elevated Serum Interleukin-23 Levels in Patients with Oral and Cutaneous Lichen Planus.
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DOI：
10.1155/2021/5578568
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发表时间：
2021
影响因子：
4.6
通讯作者：
Hamidizadeh N
中科院分区：
文献类型：
--
作者：
Mardani M;Mofidi H;Dastgheib L;Ranjbar S;Hamidizadeh N
扁平苔藓被认为是一种慢性炎症性疾病，可影响不同部位，如皮肤、粘膜、头发和指甲。有证据表明，一个复杂的细胞因子网络在扁平苔藓的发病过程中起着至关重要的作用。该研究旨在评估皮肤和口腔扁平苔藓患者与健康对照者的血清IL-23水平。方法。本研究纳入皮肤扁平苔藓患者30例，口腔扁平苔藓患者20例，对照组33例。每位患者取5毫升外周血，分离血清。采用ELISA试剂盒检测IL-23水平，采用Mann-Whitney试验分析数据。结果。口腔扁平苔藓患者血清IL-23水平显著高于对照组（P值≤0.001）。此外，与健康对照组相比，皮肤扁平苔藓患者血清IL-23水平有显著差异（P值≤0.001）。皮肤扁平苔藓患者与口腔扁平苔藓患者血清IL-23水平差异有统计学意义（P值≤0.001）。根据白细胞介素-23的平均浓度，口腔扁平苔藓患者的IL-23水平高于皮肤扁平苔藓患者。结论。口腔扁平苔藓患者血清IL-23水平升高可能提示IL-23在口腔扁平苔藓的发病机制中起着至关重要的作用。然而，需要更多的研究和更大的样本量。
Lichen planus is considered a chronic inflammatory disease which affects different sites, such as the skin, mucous membranes, hair, and nails. Based on the evidence, a complex cytokine network plays a crucial role in lichen planus pathogenesis. The study was aimed at assessing the serum IL-23 levels in the patients with cutaneous and oral lichen planus compared to healthy controls. Method. The study included 30 cutaneous lichen planus patients, 20 oral lichen planus patients, and 33 control subjects. Five milliliters of peripheral blood was obtained from each patient, and the serum was separated. IL-23 levels were determined using the ELISA kit, and the data were analyzed using the Mann–Whitney test. Results. IL-23 levels in the patient serum with oral lichen planus (P value ≤ 0.001) were significantly higher than in controls. Furthermore, there were significant differences in IL-23 serum levels in the patients with cutaneous lichen planus compared to the healthy controls (P value ≤ 0.001). Moreover, IL-23 serum levels were statistically different between patients with cutaneous lichen planus and patients with oral lichen planus (P value ≤ 0.001). Based on the mean concentration of interleukin-23, IL-23 levels were higher in the patients with oral lichen planus than in the patients with cutaneous lichen planus. Conclusions. Elevated serum IL-23 levels in the patients with oral lichen planus may indicate that IL-23 plays a crucial role in the pathogenesis of oral lichen planus. However, more research is needed with a larger sample size.
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DOI：
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发表时间：
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期刊：
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