Sexual differentiation of the zebra finch song system: potential roles for sex chromosome genes.
Sexual differentiation of the zebra finch song system: potential roles for sex chromosome genes.
复制标题
DOI：
10.1186/1471-2202-10-24
复制
发表时间：
2009-03-23
期刊：
影响因子：
2.4
通讯作者：
Wade J
中科院分区：
文献类型：
--
作者：
Tomaszycki ML;Peabody C;Replogle K;Clayton DF;Tempelman RJ;Wade J
最近的证据表明，大脑和行为的某些性别差异可能是由直接的遗传效应造成的，而不仅仅是类固醇激素的组织效应的结果。本研究探讨了性别偏向基因表达在幼年斑胸草雀性二态鸣唱行为和相关鸣唱核发育中的潜在作用。微阵列筛选显示超过2400个假定的基因（错误发现率小于0.05）在发育中的斑胸草雀的端脑表现出性别差异。使用整个端脑的cDNA，通过qPCR在20只雄性中的12只中证实了表达增加;所有这些似乎都位于Z性染色体上。六个基因也表现出增加的表达在一个或多个的歌曲控制核的男性在孵化后第25天。虽然一半的基因的功能是目前未知的，我们已经确定了三个：17-β-羟基类固醇脱氢酶IV型，甲基巴豆酰辅酶A羧化酶，和排序连接蛋白2。这些数据表明，这些基因在歌曲学习和/或男性化的歌曲系统形态，这两者都发生在这个发展阶段的潜在影响。
Recent evidence suggests that some sex differences in brain and behavior might result from direct genetic effects, and not solely the result of the organizational effects of steroid hormones. The present study examined the potential role for sex-biased gene expression during development of sexually dimorphic singing behavior and associated song nuclei in juvenile zebra finches. A microarray screen revealed more than 2400 putative genes (with a false discovery rate less than 0.05) exhibiting sex differences in the telencephalon of developing zebra finches. Increased expression in males was confirmed in 12 of 20 by qPCR using cDNA from the whole telencephalon; all of these appeared to be located on the Z sex chromosome. Six of the genes also showed increased expression in one or more of the song control nuclei of males at post-hatching day 25. Although the function of half of the genes is presently unknown, we have identified three as: 17-beta-hydroxysteroid dehydrogenase type IV, methylcrotonyl-CoA carboxylase, and sorting nexin 2. The data suggest potential influences of these genes in song learning and/or masculinization of song system morphology, both of which are occurring at this developmental stage.
登录
查看更多内容
影响因子：
3.8
作者：
Darin, Niklas;Andersen, Oluf;Holme, Elisabeth
通讯作者：
Holme, Elisabeth
DOI：
10.1073/pnas.0409558102
发表时间：
2005-10-18
影响因子：
11.1
作者：
Griffin, CT;Trejo, J;Magnuson, T
通讯作者：
Magnuson, T
DOI：
10.1016/s0169-328x(03)00339-5
发表时间：
2003-10-21
期刊：
MOLECULAR BRAIN RESEARCH
影响因子：
--
作者：
Dewing, P;Shi, T;Vilain, E
通讯作者：
Vilain, E
DOI：
10.1196/annals.1298.042
发表时间：
2004-01-01
期刊：
BEHAVIORAL NEUROBIOLOGY OF BIRDSONG
影响因子：
--
作者：
Brainard, MS
通讯作者：
Brainard, MS
影响因子：
2.5
作者：
CLAYTON, NS
通讯作者：
CLAYTON, NS