DNA Methylation and HPV-Associated Head and Neck Cancer.
DNA Methylation and HPV-Associated Head and Neck Cancer.
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DOI：
10.3390/microorganisms9040801
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发表时间：
2021-04-10
期刊：
影响因子：
4.5
通讯作者：
Kaneda A
中科院分区：
文献类型：
--
作者：
Nakagawa T;Kurokawa T;Mima M;Imamoto S;Mizokami H;Kondo S;Okamoto Y;Misawa K;Hanazawa T;Kaneda A
头颈部鳞状细胞癌（HNSCC），尤其是口咽部鳞状细胞癌（OPSCC），最近发现与人乳头瘤病毒（HPV）感染显著相关。OPSCC的发病率一直在增加，并超过了美国宫颈癌病例的数量。虽然HPV相关OPSCC的预后比HPV阴性癌症相对更好，但约20%的HPV相关HNSCC患者的预后或治疗反应较差，并且中危组中这种结果背后的分子机制尚未阐明。HPV相关HNSCC和HPV阴性HNSCC之间的这些生物学差异部分由突变模式的差异解释。然而，最近的报告显示，表观遗传失调，如失调的DNA甲基化，是一个惊人的共同病理特征的人类恶性肿瘤。值得注意的是，病毒感染可诱导异常的DNA甲基化，导致致癌，并且HPV相关的HNSCC病例往往比HPV阴性的HNSCC病例含有更高量的异常甲基化DNA。此外，最近对大型队列进行的全基因组DNA甲基化分析显示，HPV相关HNSCC的一个亚组与DNA甲基化增加相关。因此，在这篇综述中，我们提供了DNA甲基化和HPV相关的HNSCC之间的关系的概述。
Head and neck squamous cell carcinoma (HNSCC), especially oropharyngeal squamous cell carcinoma (OPSCC), has recently been found to be significantly associated with human papillomavirus (HPV) infection. The incidence of OPSCC has been increasing and surpassed the number of cervical cancer cases in the United States. Although HPV-associated OPSCC has a relatively better prognosis than HPV-negative cancer, approximately 20% of HPV-associated HNSCC patients show a poor prognosis or therapeutic response, and the molecular mechanism behind this outcome in the intermediate-risk group is yet to be elucidated. These biological differences between HPV-associated HNSCC and HPV-negative HNSCC are partly explained by the differences in mutation patterns. However, recent reports have revealed that epigenetic dysregulation, such as dysregulated DNA methylation, is a strikingly common pathological feature of human malignancy. Notably, viral infections can induce aberrant DNA methylation, leading to carcinogenesis, and HPV-associated HNSCC cases tend to harbor a higher amount of aberrantly methylated DNA than HPV-negative HNSCC cases. Furthermore, recent comprehensive genome-wide DNA-methylation analyses with large cohorts have revealed that a sub-group of HPV-associated HNSCC correlates with increased DNA methylation. Accordingly, in this review, we provide an overview of the relationship between DNA methylation and HPV-associated HNSCC.
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