Impact of environmental chemicals on lung development.
Impact of environmental chemicals on lung development.
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DOI：
10.1289/ehp.0901856
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发表时间：
2010-08
影响因子：
10.4
通讯作者：
Marty MA
中科院分区：
文献类型：
--
作者：
Miller MD;Marty MA
基本生物过程和相关信号事件的破坏可能会导致肺部发育发生临床上显着的改变。我们回顾了环境化学物质对肺发育和肺形态发生中关键信号事件影响的证据，以及潜在结果与公共卫生和监管科学的相关性。我们评估了有关发育性肺生物学和毒理学、机制研究和支持流行病学的同行评审文献。婴儿期的肺功能可预测终生的肺功能。在子宫内和产后早期暴露会影响儿童和成人的肺部结构和功能，并可能使个体易患慢性阻塞性肺病和其他疾病。营养和内源性化学环境影响肺的发育，并可能导致成人功能改变。现在的研究表明，在生命早期的关键时期接触环境相关剂量的某些外源物质后，动物和人类可能会发生类似的不利影响。潜在的机制包括干扰发育过程中高度保守的因子，例如基因调控、分子信号传导以及参与分支形态发生和肺泡化的生长因子。评估环境化学物质对肺部的影响需要进行评估结构或功能的具体改变的研究——标准毒性测试中不定期评估的终点。识别对重要信号事件的影响可以为发育毒理学研究方案提供信息。这些知识可能有助于制定促进肺部疾病真正一级预防的政策。在缺乏足够的发育毒理学数据的情况下相关信号传导中断的证据应该会影响风险评估中使用的不确定因素的大小。
Disruption of fundamental biologic processes and associated signaling events may result in clinically significant alterations in lung development. We reviewed evidence on the impact of environmental chemicals on lung development and key signaling events in lung morphogenesis, and the relevance of potential outcomes to public health and regulatory science. We evaluated the peer-reviewed literature on developmental lung biology and toxicology, mechanistic studies, and supporting epidemiology. Lung function in infancy predicts pulmonary function throughout life. In utero and early postnatal exposures influence both childhood and adult lung structure and function and may predispose individuals to chronic obstructive lung disease and other disorders. The nutritional and endogenous chemical environment affects development of the lung and can result in altered function in the adult. Studies now suggest that similar adverse impacts may occur in animals and humans after exposure to environmentally relevant doses of certain xenobiotics during critical windows in early life. Potential mechanisms include interference with highly conserved factors in developmental processes such as gene regulation, molecular signaling, and growth factors involved in branching morphogenesis and alveolarization. Assessment of environmental chemical impacts on the lung requires studies that evaluate specific alterations in structure or function—end points not regularly assessed in standard toxicity tests. Identifying effects on important signaling events may inform protocols of developmental toxicology studies. Such knowledge may enable policies promoting true primary prevention of lung diseases. Evidence of relevant signaling disruption in the absence of adequate developmental toxicology data should influence the size of the uncertainty factors used in risk assessments.
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影响因子：
3.8
作者：
Fanucchi, MV;Buckpitt, AR;Plopper, CG
通讯作者：
Plopper, CG
影响因子：
2.7
作者：
Desai, TJ;Malpel, S;Cardoso, WV
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Cardoso, WV
DOI：
10.1152/ajplung.00027.2006
发表时间：
2006-10-01
影响因子：
4.9
作者：
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通讯作者：
Schelegle, Edward S.
影响因子：
10
作者：
Canoy, Dexter;Pekkanen, Juha;Jarvelin, Marjo-Riitta
通讯作者：
Jarvelin, Marjo-Riitta
影响因子：
3.8
作者：
Fenton, SE;Hamm, JT;Youngblood, GL
通讯作者：
Youngblood, GL