High contrast cartilaginous endplate imaging using a 3D adiabatic inversion-recovery-prepared fat-saturated ultrashort echo time (3D IR-FS-UTE) sequence.
High contrast cartilaginous endplate imaging using a 3D adiabatic inversion-recovery-prepared fat-saturated ultrashort echo time (3D IR-FS-UTE) sequence.
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DOI：
10.1002/nbm.4579
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发表时间：
2021-10
影响因子：
2.9
通讯作者：
Ma YJ
中科院分区：
文献类型：
--
作者：
Lombardi AF;Wei Z;Wong J;Carl M;Lee RR;Wallace M;Masuda K;Chang EY;Du J;Ma YJ
超短回波时间（UTE）序列可以对横向T2/T2* 弛豫过短而无法在常规临床MRI序列上有效观察的组织成像，例如椎体软骨终板（CEP）。在这里，我们描述了一个3D绝热反转恢复准备脂肪饱和超短回波时间（3D IR-FS-UTE）序列，以突出椎体的CEP相比，椎间盘（IVD）和骨髓脂肪（BF）在3 T。IR-FS-UTE序列使用3D UTE序列，结合以水峰和脂肪峰中间为中心的绝热IR准备脉冲，而脂肪饱和模块用于抑制来自脂肪的信号。选择性半脉冲用于信号激励，三维中心外圆锥轨迹用于更有效的数据采样。将3D IR-FS-UTE序列应用于离体人类脊柱样本以及六名健康志愿者和三名背痛患者的脊柱。在健康IVD中发现代表CEP信号的明亮连续线。6名志愿者的CEP和BF之间的实测对比噪声比（CNR）为18.5±4.9，CEP和IVD之间的实测对比噪声比（CNR）为20.3±4.15。异常IVD在样本和患者研究中显示CEP不连续或不规则。总之，所提出的3D IR-FS-UTE序列是可行的，用于椎体CEP的高对比度活体成像。
Ultrashort echo time (UTE) sequences can image tissues with transverse T2/T2* relaxations too short to be efficiently observed on routine clinical MRI sequences, such as the vertebral body cartilaginous endplate (CEP). Here, we describe a 3D adiabatic inversion recovery-prepared fat-saturated ultrashort echo time (3D IR-FS-UTE) sequence to highlight the CEP of vertebral bodies in comparison to the intervertebral disc (IVD) and bone marrow fat (BF) at 3T. The IR-FS-UTE sequence used a 3D UTE sequence combined with an adiabatic IR preparation pulse centered in the middle of the water and fat peaks, while a fat saturation module was used to suppress the signal from fat. A slab-selective half pulse was used for signal excitation, and a 3D center-out cones trajectory was used for more efficient data sampling. The 3D IR-FS-UTE sequence was applied to an ex vivo human spine sample, as well as the spines of six healthy volunteers and of three patients with back pain. Bright continue lines representing signal from CEP were found in healthy IVDs. The measured contrast-to-noise ratio (CNR) was 18.5±4.9 between the CEP and BF, and 20.3±4.15 between the CEP and IVD for the six volunteers. Abnormal IVDs showed CEP discontinuity or irregularity in the sample and patients’ studies. In conclusion, the proposed 3D IR-FS-UTE sequence is feasible for imaging of the vertebral body’s CEP in vivo with high contrast.
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DOI：
10.1016/s0140-6736(18)32203-7
发表时间：
2018-11-10
期刊：
Lancet (London, England)
影响因子：
--
作者：
GBD 2017 Causes of Death Collaborators
通讯作者：
GBD 2017 Causes of Death Collaborators
影响因子：
3.3
作者：
Du J;Takahashi AM;Bae WC;Chung CB;Bydder GM
通讯作者：
Bydder GM
影响因子：
5.9
作者：
Kühn JP;Hernando D;Meffert PJ;Reeder S;Hosten N;Laqua R;Steveling A;Ender S;Schröder H;Pillich DT
通讯作者：
Pillich DT
影响因子：
19.7
作者：
Fields, Aaron J.;Han, Misung;Lotz, Jeffrey C.
通讯作者：
Lotz, Jeffrey C.
影响因子：
3.3
作者：
Gurney, PT;Hargreaves, BA;Nishimura, DG
通讯作者：
Nishimura, DG