Proton-density fat fraction and simultaneous R2* estimation as an MRI tool for assessment of osteoporosis.
Proton-density fat fraction and simultaneous R2* estimation as an MRI tool for assessment of osteoporosis.
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DOI：
10.1007/s00330-013-2950-7
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发表时间：
2013-12
影响因子：
5.9
通讯作者：
Pillich DT
中科院分区：
文献类型：
--
作者：
Kühn JP;Hernando D;Meffert PJ;Reeder S;Hosten N;Laqua R;Steveling A;Ender S;Schröder H;Pillich DT
探讨骨髓中质子密度脂肪分数（PDFF）和脂肪校正R2* 的多回波化学位移编码MRI标测作为骨质疏松评估的生物标志物。51名患者（28名女性;平均年龄69.7 ± 9.0岁）接受了双能X线吸收测定法（DXA）。根据t值，将173个有效椎体分为三组（健康组、骨质疏松组和骨质疏松组）。在3 T下采集三个回波化学位移编码的MRI序列。测量每个椎体的PDFF和R2*，并校正多峰脂肪（R2*MP）。进行Kruskal-Wallis检验和事后分析以评价组间差异。此外，使用逻辑回归分析计算每种技术的曲线下面积（AUC）。DXA结果显示正常92例（53%），骨质减少47例（27%），骨质疏松34例（20%）.骨质疏松组PDFF较健康组增高（P=0.007）。R2*MP在正常与骨量减少组之间有显著性差异（P=0.004），在正常与骨质疏松组之间有显著性差异（P<0.001）。R2*MP区分正常和骨质疏松的AUC为0.698，PDFF为0.656，两者合并为0.74。PDFF和R2*MP是骨质疏松症的中度生物标志物。PDFF和R2*MP联合应用可提高对健康受试者和骨质疏松患者的预测能力。
To investigate multi-echo chemical shift-encoded MRI-based mapping of proton density fat fraction (PDFF) and fat-corrected R2* in bone marrow as biomarkers for osteoporosis assessment. Fifty-one patients (28 female; mean age 69.7 ± 9.0 years) underwent dual energy X-ray absorptiometry (DXA). On the basis of the t score, 173 valid vertebrae bodies were divided into three groups (healthy, osteopenic and osteoporotic). Three echo chemical shift-encoded MRI sequences were acquired at 3 T. PDFF and R2* with correction for multiple-peak fat (R2*MP) were measured for each vertebral body. Kruskal–Wallis test and post hoc analysis were performed to evaluate differences between groups. Further, the area under the curve (AUC) for each technique was calculated using logistic regression analysis. On the basis of DXA, 92 samples were normal (53 %), 47 osteopenic (27 %) and 34 osteoporotic (20 %). PDFF was increased in osteoporosis compared with healthy (P=0.007). R2*MP showed significant differences between normal and osteopenia (P=0.004), and between normal and osteoporosis (P<0.001). AUC to differentiate between normal and osteoporosis was 0.698 for R2*MP, 0.656 for PDFF and 0.74 for both combined. PDFF and R2*MP are moderate biomarkers for osteoporosis. PDFF and R2*MP combination might improve the prediction in differentiating healthy subjects from those with osteoporosis.
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影响因子：
3.3
作者：
Hernando, Diego;Liang, Zhi-Pei;Kellman, Peter
通讯作者：
Kellman, Peter
DOI：
10.1055/s-2008-1032492
发表时间：
1994-07-01
期刊：
FORTSCHRITTE AUF DEM GEBIETE DER RONTGENSTRAHLEN UND DER NEUEN BILDGEBENDEN VERFAHREN
影响因子：
--
作者：
FUNKE, M;BRUHN, H;GRABBE, E
通讯作者：
GRABBE, E
影响因子：
19.7
作者：
Kuehn, Jens-Peter;Hernando, Diego;Reeder, Scott B.
通讯作者：
Reeder, Scott B.
影响因子：
4.4
作者：
Hines, Catherine D. G.;Frydrychowicz, Alex;Hamilton, Gavin;Tudorascu, Dana L.;Vigen, Karl K.;Yu, Huanzhou;McKenzie, Charles A.;Sirlin, Claude B.;Brittain, Jean H.;Reeder, Scott B.
通讯作者：
Reeder, Scott B.
影响因子：
3.3
作者：
Maris, TG;Damilakis, J;Gourtsoyiannis, N
通讯作者：
Gourtsoyiannis, N