Cancer-related fatigue: the impact of skeletal muscle mass and strength in patients with advanced cancer.
Cancer-related fatigue: the impact of skeletal muscle mass and strength in patients with advanced cancer.
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DOI：
10.1007/s13539-010-0016-0
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发表时间：
2010-12
期刊：
影响因子：
--
通讯作者：
Morais JA
中科院分区：
文献类型：
--
作者：
Kilgour RD;Vigano A;Trutschnigg B;Hornby L;Lucar E;Bacon SL;Morais JA
尽管劳力性疲劳与骨骼肌质量和力量直接负相关，但目前尚不清楚这些变量是否与癌症相关疲劳（CRF）相关。因此，本研究的目的是确定 CRF 是否与晚期癌症患者 (ACP) 的四肢瘦肌肉质量和力量测量相关。 84 名新诊断（≤6 个月）患有无法手术（III-IV 期）胃肠道癌或非小细胞肺癌的患者（48 名男性，36 名女性，年龄 61.6±13.2 岁）参与了这项研究。所有患者均完成了简要疲劳调查表 (BFI)。分别使用等长测力法和等速测力法评估握力（HGS）和股四头肌（QS）力量。骨骼肌质量指数 (SMMI) 是通过双能 X 射线吸收法测量的四肢去脂质量除以身高的平方计算得出的。单变量分析显示，BFI 与体重指数、体重减轻、贫血、低蛋白血症、活动水平、疼痛、抑郁和肌肉减少症以及 SMMI、HGS 和 QS 显着相关。 HGS（r = −0.34；p = 0.018）、QS（r = −0.39；p = 0.024）和SMMI（r = −0.60；p < 0.001）与男性的BFI总分呈负相关，但在女性中则不然。当调整性别、年龄、诊断、生存率以及上述特征时，多变量分析显示，BFI评分与HGS（B = −0.90；95% CI -1.5：−0.3）、QS（−0.2；−0.3：−0.01）和SMMI（−7.5；−13.0：−2.0）呈负相关。存在显着的性别 × SMMI 交互作用（10.8；1.2：20.5），其中男性的 BFI 随着 SMMI 的增加而降低，但女性的 BFI 不随 SMMI 的变化而变化。这些结果表明，在 ACP 中，CRF 与肌肉质量和力量相关，这可能为未来的干预提供目标。
Although exertional fatigue is directly and negatively related to skeletal muscle mass and strength, it is currently unknown if these variables are associated with cancer-related fatigue (CRF). Therefore, the purpose of this study was to determine if CRF is associated with measures of appendicular lean muscle mass and strength in advanced cancer patients (ACP). Eighty-four patients (48 men, 36 women aged 61.6 ± 13.2 year) newly diagnosed (≤6 months) with inoperable (Stages III–IV) gastrointestinal or non-small cell lung cancer participated in this study. All patients completed the Brief Fatigue Inventory (BFI). Handgrip (HGS) and quadriceps (QS) strength were assessed using isometric and isokinetic dynamometry, respectively. Skeletal muscle mass index (SMMI) was calculated from the appendicular lean mass measured via dual-energy X-ray absorptiometry divided by body height squared. Univariate analysis showed BFI to be significantly associated with body mass index, weight loss, anemia, hypoalbuminemia, activity level, pain, depression, and sarcopenia along with SMMI, HGS, and QS. HGS (r = −0.34; p = 0.018), QS (r = −0.39; p = 0.024), and SMMI (r = −0.60; p < 0.001) were negatively correlated with BFI total scores in men but not in women. When adjusted for sex, age, diagnosis, survival, along with the above characteristics, multivariate analyses showed that BFI scores were negatively associated with HGS (B = −0.90; 95% CI −1.5:−0.3), QS (−0.2; −0.3:−0.01), and SMMI (−7.5; −13.0:−2.0). There was a significant sex × SMMI interaction (10.8; 1.2:20.5), where BFI decreased with increasing SMMI in men, but did not change with SMMI in women. These results suggest that in ACP, CRF is related to muscle mass and strength, which may provide targets for future interventions.
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影响因子：
3.3
作者：
Goodpaster, BH;Carlson, CL;Newman, AB
通讯作者：
Newman, AB
影响因子：
8.4
作者：
Jager, A.;Sleijfer, S.;van der Rijt, C. C. D.
通讯作者：
van der Rijt, C. C. D.
DOI：
10.1093/gerona/61.1.72
发表时间：
2006-01-01
影响因子：
5.1
作者：
Newman, AB;Kupelian, V;Harris, TB
通讯作者：
Harris, TB
影响因子：
45.3
作者：
Demetri, GD;Kris, M;Cella, D
通讯作者：
Cella, D
影响因子：
3.1
作者：
Khalid, U.;Spiro, A.;Andreyev, H. J. N.
通讯作者：
Andreyev, H. J. N.