Data-driven gated PET/CT: implications for lesion segmentation and quantitation.
Data-driven gated PET/CT: implications for lesion segmentation and quantitation.
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DOI：
10.1186/s40658-021-00411-5
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发表时间：
2021-08-28
期刊：
影响因子：
4
通讯作者：
Pan T
中科院分区：
文献类型：
--
作者：
Thomas MA;Pan T
数据驱动门控 (DDG) 可以改善 PET 定量并缓解患者运动的许多问题。然而，由于 PET 和 CT 的时间分辨率不同，DDG-PET 和 CT 之间可能会出现重合失调，并且可以通过 DDG-CT 来缓解。在这里，使用新的 DDG-PET/CT 方法评估了配准错误和呼吸运动对 PET 定量和病变分割的影响。在配准错误的区域获取低剂量电影 CT，以实现平均 CT (ACT) 和 DDG-CT。比较以下内容：（1）基线PET/CT，（2）PET/ACT（衰减校正，AC = ACT），（3）DDG-PET（AC = 螺旋CT）和（4）DDG-PET/CT（AC = DDG-CT）。对于 DDG-PET，呼气末 (EE) 数据来自总 PET 数据的 50%，30% 来自吸气末。对于 DDG-CT，EE 期 CT 数据是通过肺亨斯菲尔德单位 (HU) 值和身体轮廓从电影 CT 数据中提取的。对来自 16 名连续患者的总共 91 个病灶进行了标准摄取值 (SUV)、病灶糖酵解 (LG)、病灶体积、质心到质心距离 (CCD) 和 DICE 系数的变化评估。相对于基线 PET/CT，PET/ACT、DDG-PET 和 DDG-PET/CT 的所有 91 个病灶的 SUVmax ± σ 中位变化分别为 20±±43%、26±±23% 和 66±±66%。病变体积的中位变化为0 ±58％、- 36 ± 26％和- 26 ± 40％。 PET/ACT 中单个病变的 LG 值增加，DDG-PET 中单个病变的 LG 值降低，但 DDG-PET/CT 中没有差异。对于 PET/ACT 和 DDG-PET/CT 中的大多数病变，平均 HU 相对于基线 PET/CT 的变化非常显着，特别是对于基线时平均 HU< 0 的病变。与 ACT 或 DDG-CT 的配准改进相比，DDG-PET 运动校正对 CCD 和 DICE 的影响更大。随着重合失调变得更加突出，DDG-PET 运动校正的影响会减弱。 DDG-PET 在精确病灶分割和定量方面的潜在优势只有与 DDG-CT 结合才能充分实现。这些结果表明，必须同时考虑重合失调和运动校正，以优化 PET/CT 的临床效用。在线版本包含可在 10.1186/s40658-021-00411-5 获取的补充材料。
Data-driven gating (DDG) can improve PET quantitation and alleviate many issues with patient motion. However, misregistration between DDG-PET and CT may occur due to the distinct temporal resolutions of PET and CT and can be mitigated by DDG-CT. Here, the effects of misregistration and respiratory motion on PET quantitation and lesion segmentation were assessed with a new DDG-PET/CT method. A low-dose cine-CT was acquired in misregistered regions to enable both average CT (ACT) and DDG-CT. The following were compared: (1) baseline PET/CT, (2) PET/ACT (attenuation correction, AC = ACT), (3) DDG-PET (AC = helical CT), and (4) DDG-PET/CT (AC = DDG-CT). For DDG-PET, end-expiration (EE) data were derived from 50% of the total PET data at 30% from end-inspiration. For DDG-CT, EE phase CT data were extracted from cine-CT data by lung Hounsfield unit (HU) value and body contour. A total of 91 lesions from 16 consecutive patients were assessed for changes in standard uptake value (SUV), lesion glycolysis (LG), lesion volume, centroid-to-centroid distance (CCD), and DICE coefficients. Relative to baseline PET/CT, median changes in SUVmax ± σ for all 91 lesions were 20 ± 43%, 26 ± 23%, and 66 ± 66%, respectively, for PET/ACT, DDG-PET, and DDG-PET/CT. Median changes in lesion volume were 0 ± 58%, − 36 ± 26%, and − 26 ± 40%. LG for individual lesions increased for PET/ACT and decreased for DDG-PET, but was not different for DDG-PET/CT. Changes in mean HU from baseline PET/CT were dramatic for most lesions in both PET/ACT and DDG-PET/CT, especially for lesions with mean HU < 0 at baseline. CCD and DICE were both affected more by motion correction with DDG-PET than improved registration with ACT or DDG-CT. As misregistration becomes more prominent, the impact of motion correction with DDG-PET is diminished. The potential benefits of DDG-PET toward accurate lesion segmentation and quantitation could only be fully realized when combined with DDG-CT. These results impress upon the necessity of ensuring both misregistration and motion correction are accounted for together to optimize the clinical utility of PET/CT. The online version contains supplementary material available at 10.1186/s40658-021-00411-5.
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影响因子：
9.3
作者：
Hamill, James J.;Meier, Joseph G.;Mawlawi, Osama
通讯作者：
Mawlawi, Osama
DOI：
10.1016/j.ijrobp.2020.11.014
发表时间：
2021-04-01
期刊：
International journal of radiation oncology, biology, physics
影响因子：
--
作者：
Pan T;Lu Y;Thomas MA;Liao Z;Luo D
通讯作者：
Luo D
影响因子：
2.7
作者：
Benjamini, Yoav;Krieger, Abba M.;Yekutieli, Daniel
通讯作者：
Yekutieli, Daniel
影响因子：
1.5
作者：
Pépin A;Daouk J;Bailly P;Hapdey S;Meyer ME
通讯作者：
Meyer ME
影响因子：
3.8
作者：
Kesner, Adam L.;Meier, Joseph G.;Lynch, David A.
通讯作者：
Lynch, David A.