Multifaceted interactions between adaptive immunity and the central nervous system.
Multifaceted interactions between adaptive immunity and the central nervous system.
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DOI：
10.1126/science.aag2638
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发表时间：
2016-08-19
期刊：
影响因子：
--
通讯作者：
Kipnis J
中科院分区：
文献类型：
--
作者：
Kipnis J
神经免疫学家试图了解中枢神经系统（CNS）和免疫系统之间的相互作用，无论是在稳态条件下还是在疾病中。尚未回答的问题包括与脑膜T细胞库的多样性和特异性有关的问题;在健康条件下巡逻脑膜和在病理过程中侵入脑实质的免疫细胞所采取的路线;相反的影响。这些细胞对CNS功能的作用（有益或有害）;免疫细胞在CNS损伤后的作用;以及两个系统之间的进化联系，导致它们之间的紧密互动和相互依赖。本文综述了适应性免疫和中枢神经系统之间相互作用的现状和挑战性问题，并考虑了未来十年神经免疫学这些方面的可能方向。
Neuroimmunologists seek to understand the interactions between the central nervous system (CNS) and the immune system, both under homeostatic conditions and in diseases. Unanswered questions include those relating to the diversity and specificity of the meningeal T cell repertoire; the routes taken by immune cells that patrol the meninges under healthy conditions and invade the parenchyma during pathology; the opposing effects (beneficial or detrimental) of these cells on CNS function; the role of immune cells after CNS injury; and the evolutionary link between the two systems, resulting in their tight interaction and interdependence. This Review summarizes the current standing of and challenging questions related to interactions between adaptive immunity and the CNS and considers the possible directions in which these aspects of neuroimmunology will be heading over the next decade.
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