β-hairpin peptide hydrogels for package delivery.
β-hairpin peptide hydrogels for package delivery.
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DOI：
10.1016/j.addr.2017.02.002
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发表时间：
2017-03
影响因子：
16.1
通讯作者：
Pochan D
中科院分区：
文献类型：
--
作者：
Worthington P;Langhans S;Pochan D
药物输送的潜在挑战是以有效剂量将治疗剂供应安全、受控地运输到其预期位置。在水凝胶领域正在发现有效载荷递送的新的和扩展的解决方案。水凝胶是高度水合的聚合物网络，其根据基础分子结构而变化很大。本章重点讨论的水凝胶亚组是β-发夹肽水凝胶。这些基于肽的材料通过分子自组装机制形成，该分子自组装机制仅在分子内肽折叠的期望触发之后发生。一旦折叠，β-发夹在分子间组装成纳米原纤网络。水凝胶网络的物理性质及其肽基础导致有利的材料性质，其可用于多种生物医学应用，包括药物递送。作为一种易于注射、细胞相容、可定制和良好表征的剪切稀化固体，β-发夹水凝胶是作为药物递送载体的令人兴奋的候选者。
The underlying challenge of drug delivery is the safe, controlled transport of a supply of therapeutic agent to its intended location at its effective dose. New and expanding solutions to payload delivery are being discovered in the field of hydrogels. Hydrogels are highly hydrated polymer networks that vary greatly depending on the underlying molecular structure. The subgroup of hydrogels that will be the focus of this chapter is the β-hairpin peptide hydrogel. These peptide-based materials are formed through a molecular self-assembly mechanism that only occurs after desired triggering of intramolecular peptide folding. Once folded, the β-hairpins assemble intermolecularly into a nanofibrillar network. The physical properties of the hydrogel network and its peptide foundation result in advantageous material properties which can be used for multiple biomedical applications including drug delivery. As a shear thinning solid that is easily injectable, cytocompatible, customizable, and well characterized, β-hairpin hydrogels are an exciting candidate as a drug delivery vehicle.
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影响因子：
3.4
作者：
Canazza A;Minati L;Boffano C;Parati E;Binks S
通讯作者：
Binks S
影响因子：
6.2
作者：
Bakota EL;Sensoy O;Ozgur B;Sayar M;Hartgerink JD
通讯作者：
Hartgerink JD
影响因子：
14
作者：
Branco, Monica C.;Pochan, Darrin J.;Wagner, Norman J.;Schneider, Joel P.
通讯作者：
Schneider, Joel P.
影响因子：
15
作者：
Lamm, MS;Rajagopal, K;Pochan, DJ
通讯作者：
Pochan, DJ
DOI：
10.1073/pnas.0701980104
发表时间：
2007-05-08
影响因子：
11.1
作者：
Haines-Butterick, Lisa;Rajagopal, Karthikan;Schneider, Joel P.
通讯作者：
Schneider, Joel P.