Experimental models of brain ischemia: a review of techniques, magnetic resonance imaging, and investigational cell-based therapies.
Experimental models of brain ischemia: a review of techniques, magnetic resonance imaging, and investigational cell-based therapies.
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DOI：
10.3389/fneur.2014.00019
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发表时间：
2014
影响因子：
3.4
通讯作者：
Binks S
中科院分区：
文献类型：
--
作者：
Canazza A;Minati L;Boffano C;Parati E;Binks S
中风仍然是全球死亡和残疾的重要原因。尽管在过去几十年中，在预防、治疗和康复方面取得了重大进展，但在将新的治疗方法从实验室转化为临床实践方面仍然存在巨大挑战。溶栓虽然常规用于缺血性卒中，但仅在狭窄的时间窗内是一种可行的选择。最近，干细胞生物学的进展为旨在支持和替代梗死区域的神经细胞的治疗策略开辟了途径。真实的实验动物模型对于了解缺血性脑损伤后神经元存活的机制和开发治疗干预措施至关重要。目前实验性中风治疗的研究主要使用永久性或短暂性局灶性脑缺血的啮齿动物模型来评估神经保护剂和基于细胞的方法的有效性。与此同时，成像技术的进步允许更好地映射病变皮层及其功能反应的时空演变。这篇评论提供了一个浓缩的概念审查的最先进的这一领域，从模型和磁共振成像技术，通过干细胞疗法。
Stroke continues to be a significant cause of death and disability worldwide. Although major advances have been made in the past decades in prevention, treatment, and rehabilitation, enormous challenges remain in the way of translating new therapeutic approaches from bench to bedside. Thrombolysis, while routinely used for ischemic stroke, is only a viable option within a narrow time window. Recently, progress in stem cell biology has opened up avenues to therapeutic strategies aimed at supporting and replacing neural cells in infarcted areas. Realistic experimental animal models are crucial to understand the mechanisms of neuronal survival following ischemic brain injury and to develop therapeutic interventions. Current studies on experimental stroke therapies evaluate the efficiency of neuroprotective agents and cell-based approaches using primarily rodent models of permanent or transient focal cerebral ischemia. In parallel, advancements in imaging techniques permit better mapping of the spatial-temporal evolution of the lesioned cortex and its functional responses. This review provides a condensed conceptual review of the state of the art of this field, from models and magnetic resonance imaging techniques through to stem cell therapies.
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影响因子：
4
作者：
Back, T
通讯作者：
Back, T
慢性中风中的自体间充质干细胞。
影响因子：
1.9
作者：
Bhasin A;Srivastava MV;Kumaran SS;Mohanty S;Bhatia R;Bose S;Gaikwad S;Garg A;Airan B
通讯作者：
Airan B
影响因子：
8.3
作者：
Bardutzky, J;Shen, Q;Fisher, M
通讯作者：
Fisher, M
影响因子：
3
作者：
Balkaya, Mustafa;Kroeber, Jan;Endres, Matthias
通讯作者：
Endres, Matthias
缺血性脑损伤的干细胞：批判性综述。
DOI：
10.1002/cne.22038
发表时间：
2009-07-01
期刊：
The Journal of comparative neurology
影响因子：
--
作者：
Burns TC;Verfaillie CM;Low WC
通讯作者：
Low WC