Synthesis of Porous Hollow Organosilica Particles with Tunable Shell Thickness.
Synthesis of Porous Hollow Organosilica Particles with Tunable Shell Thickness.
复制标题
DOI：
10.3390/nano12071172
复制
发表时间：
2022-04-01
期刊：
影响因子：
5.3
通讯作者：
Varga, Zoltan
中科院分区：
文献类型：
--
作者：
Al-Khafaji, Mohammed A.;Gaal, Aniko;Jezso, Balint;Mihaly, Judith;Bartczak, Dorota;Goenaga-Infante, Heidi;Varga, Zoltan
多孔空心二氧化硅粒子在从药物传递到催化等许多领域具有广阔的应用前景。从合成的角度来看，最具挑战性的参数是粒径分布的单分散性以及颗粒壳的厚度和孔隙率。本文介绍了一种简单的两锅法制备具有均匀球形和良好的壳厚度的单分散多孔中空二氧化硅颗粒。该方法以1，2-二（三乙氧基硅基）乙烷（BTEE）和正硅酸乙酯（TEOS）为原料，十六烷基三甲基溴化铵（CTAB）为结构导向剂，以固体SiO2微球为核模板，通过水解缩合反应合成了一系列多孔-中空无机和有机-无机核壳结构的SiO2微球。最后，在碱性条件下通过水热处理去除核模板。采用透射电子显微镜（TEM）表征了粒子的形貌和粒径分布，采用傅里叶变换红外光谱（FTIR）跟踪了合成过程中化学组成的变化。采用单粒子电感耦合等离子体质谱（spICP-MS）对不同反应条件下制备的空心粒子的单分散性进行了表征。我们发现，BTEE的存在是获得良好定义的壳结构的关键，并且前体和表面活性剂的浓度的增加增加了壳的厚度。TEM和spICP-MS测量显示，熔融颗粒也形成在次优的反应参数下，导致尺寸分布的加宽，这可以通过使用适当浓度的BTEE、CTAB和氨来进行。
Porous hollow silica particles possess promising applications in many fields, ranging from drug delivery to catalysis. From the synthesis perspective, the most challenging parameters are the monodispersity of the size distribution and the thickness and porosity of the shell of the particles. This paper demonstrates a facile two-pot approach to prepare monodisperse porous-hollow silica particles with uniform spherical shape and well-tuned shell thickness. In this method, a series of porous-hollow inorganic and organic-inorganic core-shell silica particles were synthesized via hydrolysis and condensation of 1,2-bis(triethoxysilyl) ethane (BTEE) and tetraethyl orthosilicate (TEOS) in the presence of hexadecyltrimethylammonium bromide (CTAB) as a structure-directing agent on solid silica spheres as core templates. Finally, the core templates were removed via hydrothermal treatment under alkaline conditions. Transmission electron microscopy (TEM) was used to characterize the particles′ morphology and size distribution, while the changes in the chemical composition during synthesis were followed by Fourier-transform infrared spectroscopy. Single-particle inductively coupled plasma mass spectrometry (spICP-MS) was applied to assess the monodispersity of the hollow particles prepared with different reaction parameters. We found that the presence of BTEE is key to obtaining a well-defined shell structure, and the increase in the concentration of the precursor and the surfactant increases the thickness of the shell. TEM and spICP-MS measurements revealed that fused particles are also formed under suboptimal reaction parameters, causing the broadening of the size distribution, which can be preceded by using appropriate concentrations of BTEE, CTAB, and ammonia.
登录
查看更多内容
胶体 HPMO 纳米颗粒：二氧化硅蚀刻化学定制、拓扑转化和纳米生物医学应用
影响因子：
29.4
作者：
Chen, Yu;Xu, Pengfei;Shi, Jianlin
通讯作者：
Shi, Jianlin
影响因子：
3.9
作者：
Yu, Qiyu;Wang, Pengpeng;Wang, Xun
通讯作者：
Wang, Xun
影响因子：
3.9
作者：
Lu, Y;McLellan, J;Xia, YN
通讯作者：
Xia, YN
影响因子：
29.4
作者：
Fornasieri, G;Badaire, W;Poulin, P
通讯作者：
Poulin, P
中空二氧化硅纳米胶囊的可逆孔结构演化：用于 siRNA 递送和纳米颗粒收集的大孔
影响因子：
13.3
作者：
Chen, Yu;Chu, Chen;Shi, Jianlin
通讯作者：
Shi, Jianlin