Classification and characterization of class III malocclusion in Chinese individuals.
Classification and characterization of class III malocclusion in Chinese individuals.
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中国人Ⅲ类错牙合畸形的分类和特征
DOI：
10.1186/s13005-016-0127-8
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发表时间：
2016-11-07
影响因子：
3
通讯作者：
Chen F
中科院分区：
文献类型：
--
作者：
Li C;Cai Y;Chen S;Chen F
背景III类错牙合是一种颌面部疾病，其特征是轮廓凹，可归因于遗传和环境因素。由于我们对其病因学的了解有限，这是一个临床挑战。揭示其原型多样性将有助于我们对潜在病因学信息的连续探索。本研究的目的是通过侧位头影测量分析中国人群中 III 类错牙合的表型变异特征。方法本研究纳入了 144 名患有从轻度到重度 III 类错牙合的个体（58 名男性≥18 岁和 86 名女性≥16 岁）。使用 61 个侧向头影测量进行主成分分析和聚类分析。结果在检查人群中发现了 6 个主成分，占 73.7% 的变异性。通过聚类分析揭示了四种亚型。亚型 1 包括具有陡峭下颌平面的轻度下颌前突的受试者。亚型 2 的受试者表现出下颌前突和上颌后缩的组合，以及平坦或正常的下颌平面。亚型 3 包括纯粹严重下颌前突和正常下颌平面的个体。亚型4的个体有轻度上颌骨缺损和严重的下颌前突，下颌平面角最低。结论从61个变量中提取的6个主成分提高了我们对侧位头影测量分析诊断的认识。我们成功鉴定了四种Ⅲ类错牙合亚型，表明聚类分析可以补充中国人群中Ⅲ类错牙合的分类，并可能有助于我们正在进行的遗传学研究。
BackgroundClass III malocclusion is a maxillofacial disorder that is characterised by a concave profile and can be attributed to both genetic inheritance and environmental factors. It is a clinical challenge due to our limited understanding of its aetiology. Revealing its prototypical diversity will contribute to our sequential exploration of the underlying aetiological information. The objective of this study was to characterize phenotypic variations of Class III malocclusion via a lateral cephalometric analysis in a community of Chinese individuals.MethodOne-hundred-and-forty-four individuals (58 males ≥18 and 86 females ≥16) with Class III malocclusion ranging from mild to severe were enrolled in this study. Principal component analysis and cluster analysis were performed using 61 lateral cephalometric measurements.ResultsSix principal components were discovered in the examined population and were responsible for 73.7 % of the variability. Four subtypes were revealed by cluster analysis. Subtype 1 included subjects with mild mandibular prognathism with a steep mandibular plane. Subjects in subtype 2 showed a combination of prognathic mandibular and retrusive maxillary with a flat or normal mandibular plane. Subtype 3 included individuals with purely severe mandibular prognathism and a normal mandibular plane. Individuals in subtype 4 had a mild maxillary deficiency and severe mandibular prognathism with the lowest mandibular plane angle.ConclusionThe six principal components extracted among the 61 variables improve our knowledge of lateral cephalometric analysis for diagnoses. We successfully identified four Class III malocclusion subtypes, indicating that cluster analysis could supplement the classification of Class III malocclusion among a Chinese population and may assist in our on-going genetic study.
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影响因子：
7.6
作者：
Jang, J. Y.;Park, E. K.;Kwon, T. G.
通讯作者：
Kwon, T. G.
影响因子：
5
作者：
Chen, Chiung-Zuei;Wang, Liang-Yi;Hsiue, Tzuen-Ren
通讯作者：
Hsiue, Tzuen-Ren
影响因子：
7.6
作者：
Frazier-Bowers S;Rincon-Rodriguez R;Zhou J;Alexander K;Lange E
通讯作者：
Lange E
影响因子：
7.6
作者：
da Fontoura, C. S. G.;Miller, S. F.;Uribe, L. M. Moreno
通讯作者：
Uribe, L. M. Moreno
DOI：
10.1054/ijom.2001.0088
发表时间：
2001-08-01
影响因子：
2.4
作者：
Hong, SX;Yi, CK
通讯作者：
Yi, CK