Therapeutic Efficacy of Shexiang Baoxin Pill Combined with Exercise in Patients with Heart Failure with Preserved Ejection Fraction: A Single-Center, Double-Blind, Randomized Controlled Trial.
Therapeutic Efficacy of Shexiang Baoxin Pill Combined with Exercise in Patients with Heart Failure with Preserved Ejection Fraction: A Single-Center, Double-Blind, Randomized Controlled Trial.
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DOI：
10.1007/s11655-022-3627-3
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发表时间：
2023-02
影响因子：
2.9
通讯作者：
Wang, Lei
中科院分区：
文献类型：
--
作者：
Liu, Si-pei;Zhou, Jian-guan;Jin, Yan;Guo, Yan;Zhou, Shi-wei;Lin, Mei-lan;Zhang, Jun;Wang, Xiao-nv;Guan, Xia-fei;Wang, Lei
观察麝香保心丸配合运动治疗射血分数保留性心力衰竭（HFpEF）的疗效。将60例HFpEF患者随机分为A组（n=20）、B组（n=20）和C组（n=20），A组在常规药物治疗的基础上，给予麝香保心丸联合家庭运动训练治疗12周; B组在常规药物治疗的基础上，给予家庭运动训练治疗12周。比较各组治疗前后的峰值摄氧量（peakVO 2）、无氧阈（AT）、6 min步行试验（6 MWT）、匹兹堡睡眠质量指数（PSQI）、SF-36问卷（SF-36）结果。治疗12周后，C组患者的peakVO 2、AT、6 MWT、PSQI和SF-36较治疗前明显下降（P<0.01），而A组和B组患者的peakVO 2、AT、6 MWT、PSQI和SF-36较治疗前均明显改善（P<0.01）。与C组比较，A、B组患者的peakVO 2、AT、6 MWT、PSQI和SF-36均有显著改善（P<0.01）。此外，A组患者在SF-36问卷的身体功能、身体角色、活力和心理健康评分以及PSQI评分方面的改善比B组更明显（P<0.01）。运动训练改善HFpEF患者的运动耐量、睡眠质量和生活质量（QoL）。麝香保心丸对HFpEF患者的睡眠质量和生活质量有积极作用。(The试验在中国临床试验注册中心注册（编号ChiCTR 2100054322））
To evaluate the therapeutic efficacy of Shexiang Baoxin Pill combined with exercise in heart failure patients with preserved ejection fraction (HFpEF). Sixty patients with HFpEF were randomly divided into group A (n=20), receiving Shexiang Baoxin Pill combined with home-based exercise training based on conventional drugs for 12 weeks; group B (n=20), receiving conventional drugs combined with home-based exercise training for 12 weeks; and group C (n=20), receiving conventional drug treatment only. Peak oxygen uptake (peakVO2), anaerobic threshold (AT), 6-min walking test (6MWT), Pittsburgh Sleep Quality Index (PSQI), and SF-36 questionnaire (SF-36) results before and after treatment were compared among groups. After the 12-week intervention, patients in group C showed significant declines in peakVO2, AT, 6MWT, PSQI, and SF-36 compared with pre-treatment (P<0.01), while groups A and B both showed significant improvements in peakVO2, AT, 6MWT, PSQI, and SF-36 results compared with pre-treatment (P<0.01). Compared with group C, patients in groups A and B showed significant improvements in peakVO2, AT, 6MWT, PSQI, and SF-36 (P<0.01). In addition, patients in group A showed more significant improvements in physical function, role-physical, vitality, and mental health scores on the SF-36 questionnaire, and PSQI scores than those in group B (P<0.01). Exercise training improved exercise tolerance, sleep quality and quality of life (QoL) in patients with HFpEF. Notably, Shexiang Baoxin Pill played an active role in sleep quality and QoL of patients with HFpEF. (The trial was registered in the Chinese Clinical Trial Registry (No. ChiCTR2100054322))
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影响因子：
1.5
作者：
Awotidebe, Taofeek O.;Adeyeye, Victor O.;Balogun, Michael O.
通讯作者：
Balogun, Michael O.
影响因子：
8.3
作者：
Fukuta, Hidekatsu;Goto, Toshihiko;Ohte, Nobuyuki
通讯作者：
Ohte, Nobuyuki
DOI：
10.1186/s13102-022-00415-3
发表时间：
2022-02-07
期刊：
BMC sports science, medicine & rehabilitation
影响因子：
--
作者：
Esnaasharieh F;Dehghan M;Mangolian Shahrbabaki P
通讯作者：
Mangolian Shahrbabaki P
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影响因子：
4.6
作者：
Fang HY;Zeng HW;Lin LM;Chen X;Shen XN;Fu P;Lv C;Liu Q;Liu RH;Zhang WD;Zhao J
通讯作者：
Zhao J
影响因子：
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作者：
Hassanpour Dehkordi, Ali;Khaledi Far, Arsalan
通讯作者：
Khaledi Far, Arsalan