Sleep loss activates cellular markers of inflammation: sex differences.
Sleep loss activates cellular markers of inflammation: sex differences.
复制标题
睡眠损失激活炎症的细胞标记：性别差异。
DOI：
10.1016/j.bbi.2009.06.001
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发表时间：
2010-01
影响因子：
15.1
通讯作者：
Olmstead, Richard
中科院分区：
文献类型：
--
作者：
Irwin, Michael R.;Carrillo, Carmen;Olmstead, Richard
关键词：
睡眠障碍与炎症和相关疾病有关，包括心血管疾病、关节炎和糖尿病。考虑到炎症性疾病患病率的性别差异与女性的相关性更强，这项研究旨在测试睡眠不足对促炎细胞因子活性的细胞机制的影响。在26名健康成人(11名女性，15名男性)中，重复测定了基线期间08：00、12：00、16：00、20：00和23：00以及部分睡眠剥夺后(从晚上11点到凌晨3点)单核细胞内促炎细胞因子的产生。在一夜失眠后的早晨，单核细胞产生的白介素6和肿瘤坏死因子-α在两性之间发生了不同的变化。尽管雌性和雄性在PSD后立即在早上表现出内毒素刺激的IL-6和肿瘤坏死因子-α的产生显著增加，但这些细胞因子的产生在傍晚早些时候在雌性增加，而在雄性减少。睡眠不足会导致单核细胞致炎细胞因子反应的功能改变，与男性相比，女性表现出更大的细胞免疫活性。这些结果对理解睡眠障碍在不同性别炎症性疾病风险分布中的作用具有重要意义。
Sleep disturbance is associated with inflammation and related disorders including cardiovascular disease, arthritis, and diabetes mellitus. Given sex differences in the prevalence of inflammatory disorders with stronger associations in females, this study was undertaken to test the effects of sleep loss on cellular mechanisms that contribute to proinflammatory cytokine activity. In 26 healthy adults (11 females; 15 males), monocyte intracellular proinflammatory cytokine production was repeatedly assessed at 08:00, 12:00, 16:00, 20:00, and 23:00 h during a baseline period and after partial sleep deprivation (awake from 11 PM to 3 AM). In the morning after a night of sleep loss, monocyte production of interleukin 6 and tumor necrosis factor- α differentially changed between the two sexes. Whereas both females and males showed a marked increase in the lipopolysaccharide (LPS) - stimulated production of IL-6 and TNF-α in the morning immediately after PSD, production of these cytokines during the early- and late evening was increased in the females as compared to decreases in the males. Sleep loss induces a functional alteration of monocyte proinflammatory cytokine responses with females showing greater cellular immune activation as compared to changes in males. These results have implications for understanding the role of sleep disturbance in the differential risk profile for inflammatory disorders between the sexes.
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影响因子：
14.2
作者：
Shearer, WT;Reuben, JM;Dinges, DF
通讯作者：
Dinges, DF
影响因子：
8.3
作者：
Cappuccio, Francesco P.;Stranges, Saverio;Marmot, Michael G.
通讯作者：
Marmot, Michael G.
影响因子：
5.6
作者：
Gangwisch, James E.;Heymsfield, Steven B.;Malaspina, Dolores
通讯作者：
Malaspina, Dolores
DOI：
10.1073/pnas.0438019100
发表时间：
2003-02-18
影响因子：
11.1
作者：
Bierhaus, A;Wolf, J;Nawroth, PP
通讯作者：
Nawroth, PP
影响因子：
15.1
作者：
Irwin, M;Rinetti, G;Ehlers, C
通讯作者：
Ehlers, C