The systemic inflammation-based Glasgow Prognostic Score as a powerful prognostic factor in patients with upper tract urothelial carcinoma.
The systemic inflammation-based Glasgow Prognostic Score as a powerful prognostic factor in patients with upper tract urothelial carcinoma.
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DOI：
10.18632/oncotarget.22641
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发表时间：
2017-12-22
期刊：
影响因子：
--
通讯作者：
Azuma H
中科院分区：
文献类型：
--
作者：
Inamoto T;Matsuyama H;Sakano S;Ibuki N;Takahara K;Komura K;Takai T;Tsujino T;Yoshikawa Y;Minami K;Nagao K;Inoue R;Azuma H
C-反应蛋白和白蛋白的组合，即格拉斯哥预后评分（GPS），在各种癌症患者中具有独立的预后价值，上尿路上皮癌（UTUC）除外。本研究的目的是描述调整其他预后因素后，GPS与UTUC患者生存率之间的关系。我们查询了2个UTUC数据库。回顾性临床系列研究采用带膀胱袖状肾输尿管切除术治疗局限性UTUC患者，分析了来自山口泌尿肿瘤组和大坂医学院登记处的数据，包括年龄、膀胱癌的存在、pT分期、淋巴血管浸润、C反应蛋白（CRP）和白蛋白。将CRP和白蛋白结合构建GPS。在校正性别、年龄、ECOG体能状态（PS）、分级和淋巴血管浸润（LVI）后，通过GPS分类估计癌症特异性生存期（CSS）和总生存期（OS）以及相对超额死亡风险。确定了724例UTUC患者。我们的最终队列包括574例患者;其中，29.2%在最长16.7年的随访期间死亡。scre-0、-1和-2的GPS患者的估计平均10年CSS分别为99.5、95.1和75.9个月。GPS评分为-2的患者的10年估计平均OS最差，为67.6个月（57.2-77.9）。在调整性别、患者年龄、ECOG PS和肿瘤病灶后，GPS升高与10年时癌症死亡的过度风险也有显著相关性（GPS 2：相对过度风险= 1.74，95% CI 1.20-2.54）。GPS的CSS和OS的C指数均上级患者的年龄和肿瘤局灶性，与分级相当。GPS是局部UTUC术后CSS和OS的独立预后因素。它显著提高了已建立的预后因素的准确性。GPS可以为患者咨询和临床试验设计提供有意义的辅助手段。
The combination of C-reactive protein and albumin, the Glasgow Prognostic Score (GPS), had independent prognostic value in patients with varying cancers, except for upper tract urothelial carcinoma (UTUC). The aim of this study was to describe the relationship between GPS and survival in patients with UTUC after adjustment for other prognostic factors. We queried 2 UTUC databases. Retrospective clinical series on patients with localized UTUC managed by nephroureterectomy with bladder cuff, for whom data from the Yamaguchi Uro-Oncology Group and Osaka Medical College registry, including age, presence of bladder cancer, pT stage, lymphovascular invasion, C-reactive protein (CRP) and albumin, were analyzed. The GPS was constructed by combining CRP and albumin. Cancer specific survival (CSS) and overall survival (OS) and relative excess risk of death were estimated by GPS categories after adjusting for gender, age, ECOG performance status (PS), grade, and lymphovascular invasion (LVI). Seven hundred and twenty four UTUC patients were identified. Our final cohort included 574 patients; of these, 29.2% died during a maximum follow up of 16.7 years. The estimated mean 10-year CSS of patients with GPS of scre-0, -1, and -2 was 99.5, 95.1, and 75.9 months, respectively. Patients with GPS of score-2 had poorest 10-year estimated mean OS of 67.6 months (57.2–77.9). Raised GPS also had a significant association with excess risk of cancer death at 10 years (GPS 2: Relative Excess Risk = 1.74, 95% CI 1.20–2.54) after adjusting for gender, patients’ age, ECOG PS, and tumor focality. C-index of GPS both for CSS and OS were superior to patients’ age and tumor focality, and comparable to grade. The GPS is an independent prognostic factor for CSS and OS after surgery with curative intent for localized UTUC. It significantly increases the accuracy of established prognostic factors. The GPS may provide a meaningful adjunct for patient counseling and clinical trial design.
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影响因子：
8.8
作者：
Dalpiaz, O.;Pichler, M.;Mannweiler, S.;Hernandez, J. M. Martin;Stojakovic, T.;Pummer, K.;Zigeuner, R.;Hutterer, G. C.
通讯作者：
Hutterer, G. C.
影响因子：
3.7
作者：
Jamieson, Nigel B.;Denley, Simon M.;McMillan, Donald C.
通讯作者：
McMillan, Donald C.
影响因子：
3
作者：
Kishiki, Tomokazu;Masaki, Tadahiko;Sugiyama, Masanori
通讯作者：
Sugiyama, Masanori
影响因子：
3.7
作者：
Fang, Dong;Zhang, Lei;Zhou, Liqun
通讯作者：
Zhou, Liqun
DOI：
10.1080/01635581.2012.661512
发表时间：
2012-01-01
影响因子：
2.9
作者：
Leung, Elaine Y. L.;Roxburgh, Campbell S.;McMillan, Donald C.
通讯作者：
McMillan, Donald C.