Tooth loss, systemic inflammation, and prevalent stroke among participants in the reasons for geographic and racial difference in stroke (REGARDS) study.
Tooth loss, systemic inflammation, and prevalent stroke among participants in the reasons for geographic and racial difference in stroke (REGARDS) study.
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DOI：
10.1016/j.atherosclerosis.2008.07.037
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发表时间：
2009-04
期刊：
影响因子：
5.3
通讯作者：
Howard, George
中科院分区：
文献类型：
--
作者：
You, Zhiying;Cushman, Mary;Jenny, Nancy S.;Howard, George
牙周病导致牙齿脱落，可能导致全身炎症，并与中风有关。我们在≥45岁的白人和黑人的卒中地理和种族差异原因（REGARDS）研究的参与者中检查了牙齿脱落、炎症标志物、卒中、种族和地理区域之间的横断面相关性。我们研究了24393名参与者。通过线性回归分析牙齿脱落与炎症标志物（C-反应蛋白（CRP）、白色血细胞计数（WBC）和白蛋白）之间的关系，并通过逻辑回归分析牙齿脱落与地理区域、种族和流行性卒中之间的关系。与白人相比，黑人有1.48的优势比（95%置信区间1.37-1.60）有更多的牙齿脱落。牙齿缺失没有地理差异。与无牙齿脱落的患者相比，牙齿脱落17-32颗的患者CRP高1.17 mg/L（p < 0.0001），WBC高0.18 ×109/L（p = 0.008），白蛋白无差异，中风患病的比值比为1.28（1.09-1.49）。牙齿脱落1-16颗的患者CRP和WBC无差异，白蛋白高0.03 g/dL（p = 0.004），卒中患病率无增加。CRP或WBC没有减弱牙齿脱落和中风之间的关联。牙齿脱落，这与种族不同，但不居住地区，与炎症标志物和中风。后一种相关性未被炎症标志物混淆。
Periodontal disease results in tooth loss, may contribute to systemic inflammation, and is associated with stroke. We examined cross-sectional associations between tooth loss, inflammation markers, stroke, race, and geographic region among participants in the REasons for Geographic And Racial Differences in Stroke (REGARDS) Study of whites and blacks ≥45 years. We studied 24393 participants. Associations of tooth loss and inflammation markers (C-reactive protein (CRP), white blood cell count (WBC) and albumin) were examined by linear regression, and associations of tooth loss with geographic region, race, and prevalent stroke by logistic regression. Compared to whites, blacks had an odds ratio of 1.48 (95% confidence interval 1.37–1.60) of having more teeth lost. There were no geographic differences in tooth loss. Compared to no tooth loss, those with 17–32 teeth lost had 1.17 mg/L higher CRP (p < 0.0001) and 0.18 ×109/L higher WBC (p = 0.008), did not differ in albumin, and had an odds ratio of prevalent stroke of 1.28 (1.09–1.49). Those with 1–16 teeth lost did not differ in CRP and WBC, had 0.03 g/dL higher albumin (p = 0.004), and had no increased stroke prevalence. CRP or WBC did not attenuate associations between tooth loss and stroke. Tooth loss, which varied with race, but not region of residence, was associated with inflammation markers and stroke. The latter association was not confounded by inflammation markers.
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影响因子：
8.3
作者：
Desvarieux, M;Demmer, RT;Sacco, RL
通讯作者：
Sacco, RL
DOI：
10.1308/135576107780556806
发表时间：
2007-04-01
期刊：
Primary dental care : journal of the Faculty of General Dental Practitioners (UK)
影响因子：
--
作者：
Ford, Pauline J;Yamazaki, Kazuhisa;Seymour, Gregory J
通讯作者：
Seymour, Gregory J
影响因子：
3.3
作者：
Pow, EHN;Leung, KCM;McMillan, AS
通讯作者：
McMillan, AS
影响因子：
4.3
作者：
Beck, JD;Offenbacher, S
通讯作者：
Offenbacher, S
影响因子：
4.3
作者：
Loos, BG
通讯作者：
Loos, BG